News - Queen's Center for Biomedical Research

Drs. Sayuri Suzuki, Andrea Fleig, and colleagues identify the bioactive sites on waixenicin A that inhibit the TRPM7 channel. The manuscript has been published in the Journal of Natural Products.

April 1, 2024

In this study, Drs. Suzuki and Fleig collaborated with a multi-disciplinary of chemists and physiologists to characterize the structure-activity relationships of waixenicin A, a xenicane diterpene from the Hawaiian coral Sarcothelia edmondsoni. Waixenicin A is a selective and potent inhibitor of the TRPM7 ion channel, which is

Drs. Sayuri Suzuki, Andrea Fleig, and colleagues identify the bioactive sites on waixenicin A that inhibit the TRPM7 channel. The manuscript has been published in the Journal of Natural Products.

In this study, Drs. Suzuki and Fleig collaborated with a multi-disciplinary of chemists and physiologists to characterize the structure-activity relationships of waixenicin A, a xenicane

April 1, 2024

Dr. Sayuri Suzuki and colleagues show that the cannabinoid CBGA potently inhibits the TRPM7 channel. The manuscript has been published in the journal Function.

Dr. Suzuki’s study demonstrates that CBGA potently inhibits TRPM7 currents. Dr. Suzuki previously reported that CBGA has a potent inhibitory effect on both Store-Operated Calcium

December 8, 2023

Dr. Daniel Romo is visiting Dr. Andrea Fleig’s laboratory at the Queen’s Center for Biomedical Research.

Dr. Romo, who is Program Director of the multi-disciplinary team receiving an NIH IGNITE grant earlier this year, is visiting the research grant’s two local

December 1, 2023

Congratulations to Dr. Michael A. Ortega for being awarded an R21 grant through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH)! Dr. Ortega’s lab is based out of the Queen’s Medical Center for Biomedical Research (QCBR), where his team investigates mechanisms of kidney injury response.

The grant titled “TWEAK-Fn14 regulation of non-canonical NF-κB signaling in chronic renal inflammation,” will support the Ortega Lab for 3 years as the team focuses

August 29, 2023

It is always difficult to say goodbye to a valued team member and we are sad to see Brandon Johnson, PhD leave our department to face new challenges.

Brandon joined the Center for Biomedical Research in 2019 as Postdoctoral Fellow. He quickly advanced to Scientist, thanks to his rich experience in biophysics, calcium

August 11, 2023

Dr. Andrea Fleig and collaborators provide evidence that the TRPM7 protein is a promising target for epilepsy medication. The manuscript has been published in Epilepsia Open.

Conditions associated with low serum magnesium in humans (hypomagnesemia) can lead to seizures. The channel kinase TRPM7 is the most prominent protein in mammals that

June 16, 2023

Dr. Christine Peinelt is spending a 3-month sabbatical at QCBR

The Queen’s Center for Biomedical Research is hosting Dr. Christine Peinelt during her sabbatical leave of absence from her position as Professor and Principal Investigator

May 16, 2023

News - Media

Drs. Sayuri Suzuki, Andrea Fleig, and colleagues identify the bioactive sites on waixenicin A that inhibit the TRPM7 channel. The manuscript has been published in the Journal of Natural Products.

Drs. Sayuri Suzuki, Andrea Fleig, and colleagues identify the bioactive sites on waixenicin A that inhibit the TRPM7 channel. The manuscript has been published in the Journal of Natural Products.

Dr. Sayuri Suzuki and colleagues show that the cannabinoid CBGA potently inhibits the TRPM7 channel. The manuscript has been published in the journal Function.

Dr. Daniel Romo is visiting Dr. Andrea Fleig’s laboratory at the Queen’s Center for Biomedical Research.

It is always difficult to say goodbye to a valued team member and we are sad to see Brandon Johnson, PhD leave our department to face new challenges.

Dr. Andrea Fleig and collaborators provide evidence that the TRPM7 protein is a promising target for epilepsy medication. The manuscript has been published in Epilepsia Open.

Dr. Christine Peinelt is spending a 3-month sabbatical at QCBR

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