The Ortega Laboratory was established in March 2021 at The Queen’s Medical Center. The lab is headed by Michael Ortega, Ph.D. and located within the University of Hawaii Tower on the campus of The Queen’s Medical Center.
Dr. Ortega’s primary research interest is in cellular stress and damage response within the scope of kidney disease.
For the past couple years, he has applied these themes while studying a unique mouse model of congenital obstructive nephropathy (CON) in collaboration with Dr. Ben Fogelgren. The work identified a robust Fn14 response, which is an alternative NF-kB signaling activator, in the CON model as well as other models of acute and chronic kidney disease. Common pathology of chronic kidney disease includes ever-worsening kidney inflammation, interstitial fibrosis, and tubular atrophy.
Undergraduate Summer Researcher
Ortega M.A., Villiger R.K., Harrison-Chau M., Lieu S., Tamashiro K.-K., Lee A.J., Fujimoto B.A., Patwardhan G.Y., Kepler J., Fogelgren B.
Disease Models and Mechanisms (2022). In press.
DOI: https://doi.org/10.1101/2021.07.05.451173 PMID: in progress
Ortega M.A., Poirion O., Zu X., Huang S., Wolfgruber T.K., Sebra R., Garmire L.X.
Clin. Transl. Med. 6:41 (2017).
DOI: https://doi.org/10.1186/s40169-017-0177-y PMID: PMC574694
Ortega M.A., Ko M., Marh J., Finberg A., Oshiro M., Ward W.S.
J. Cell Biochem. 117:1806 (2016).
DOI: https://doi.org/10.1002/jcb.25480 PMID: PMC490515
Ortega M.A., Nguyen H., Ward W.S.
Cell Tissue Res. 363:195 (2016).
DOI: 10.1007/s00441-015-2296-3 PMID: PMC4703507