Publications

QCBR Publications

In vitro suppression of glioblastoma cell functions by TG100-115, a transient receptor potential melastatin 7 kinase inhibitor

Xu Y, Chen W, Alanazi R, Zhang X, Cross E, Gundi B, Rutka JT, Horgen FD, Fleig A, Feng ZP, Sun H
Advanced Neurology Medicine 4(3), 88–99 (2025)
DOI: 10.36922/AN025110023 PMID: in progress PMCID: in progress

TRPM7 in neurodevelopment and therapeutic prospects for neurodegenerative disease

Luo Z, Zhang X, Fleig A, Romo D, Hull KG, Horgen FD, Sun HS, Feng ZP
Cell Calcium 120:102886 (2024)
DOI: 10.1016/j.ceca.2024.102886 PMID: 38631163 PMCID: inprogress

Genetic evidence against involvement of TRPC proteins in SOCE, ROCE, and CRAC channel function

Susperreguy S, Yamashita M, Choi CI, Liao Y, Burch LH, Blankenship TL, Hayes E, Sliwa T, Zhang Y, Grenet D, Walker M, Plummer NW, Abramowitz J, Kinet JP, Formoso K, Johnson BE, Fleig A, Hazlehurst L, Penner R, Freichel M, Flockerzi V, Prakriya M, Birnbaumer L
Proceedings of the National Academy of Sciences of the United States of America 3;121(49):e2411389121 (2024)
DOI: 10.1073/pnas.2411389121 PMID: 39602257 PMCID: PMC11626178

TRPM7 contributes to pyroptosis and its involvement in status epilepticus

Tong X, Tong Y, Zheng J, Shi R, Liang H, Li M, Meng Y, Shi J, Zhao D, Seehus CR, Wang J, Xu X, Boczek T, Suzuki S, Fleig A, Penner R, Zhang N, Xu J, Duan J, Yu Z, Wang W, Zhao W, Guo F
Journal of Neuroinflammation 26;87(4):783-797 (2024)
DOI: 10.1186/s12974-024-03292-4 PMID: 39617893 PMCID: PMC11608501

Transient Receptor Potential Melastatin 7 (TRPM7) Ion Channel Inhibitors: Preliminary SAR and Conformational Studies of Xenicane Diterpenoids from the Hawaiian Soft Coral Sarcothelia edmondsoni

Yao G, Matthew R. Parris MR, Kuo WC, Pörzgen P, Castillo B, Mason ES, Chinchilla A, Huang J, Suzuki S, Ross R, Akana E, Vander Schuit S, Miller SP, Penner R, Sun H-S, Feng Z-P, Hull KG, Romo D, Fleig A, Horgen FD
Journal of Natural Products26;87(4):783-797 (2024)
DOI: 10.1021/acs.jnatprod.3c00942 PMID: 38537009

Cannabigerolic Acid (CBGA) inhibits the TRPM7 ion channel through its kinase domain

Suzuki S, Wakano C, Monteilh-Zoller MK, Cullen AJ, Fleig A, Penner R
Function5(1):zqad069 (2023)
DOI: 10.1093/function/zqad069 PMID: 38162115 PMCID: PMC10757070

Plasma galectin-3 is associated with decreased glomerular filtration rate in chronic HIV

Vares-Lum DL, Gangcuangco LMA, Park J, Manzano E, Ortega MA, Chow D, Shikuma C
HIV Research & Clinical Practice24(1):2261753 (2023)
DOI: 10.1080/25787489.2023.2261753 PMID: 37783570 PMCID: PMC10695702

Drugs acting at TRPM7 channels inhibit seizure-like activity

Khalil A, Shekh-Ahmad T, Kovac S, Wykes RC, Horgen FD, Fleig A, Walker MC
Epilepsia Open4:12773 (2023)
DOI: 10.1002/epi4.12773 PMID: 37328275 PMCID: PMC10472385

CBGA ameliorates inflammation and fibrosis in nephropathy

Suzuki S, Fleig A, Penner R
Scientific Reports13(1):6341 (2023)
DOI: 10.1038/s41598-023-33507-2 PMID: 37072467 PMCID: PMC10113213

Hypoxia-induced neurite outgrowth involves regulation through TRPM7

Turlova E, Ji D, Deurloo M, Wong R, Fleig A, Horgen FD, Sun HS, Feng ZP
Molecular Neurobiology 60:836-850 (2023)
DOI: 101007/s12035-022-03114-9 PMID: 36378470

Exocyst inactivation in urothelial cells disrupts autophagy and activates non-canonical NF-κB

Ortega MA, Villiger RK, Harrison-Chau M, Lieu S, Tamashiro K-K, Lee AJ, Fujimoto BA, Patwardhan GY, Kepler J, Fogelgren B
Disease Models and Mechanisms 15 (10):dmm049785 (2022)
DOI: 10.1242/dmm.049785 PMID: 36004645 PMCID: PMC9586569

Acidic cannabinoids suppress pro-inflammatory cytokine release by blocking Store-Operated Calcium Entry

Faouzi M, Wakano C, Monteilh-Zoller MK, Neupane RP, Starkus JG, Neupane JB, Cullen AJ, Johnson BE, Fleig A, Penner R
Function 3(4):zqac033 (2022)
DOI: 101093/function/zqac033 PMID: 35910331 PMCID: PMC9334010

Sex-dependent effect of aging on calcium signaling and expression of TRPM2 and CRAC channels in human neutrophils

Vázquez-Prieto M, Lascurais-Santamaria N, Fernández-Eufrasio NB, Montiel-Condado D, Garibay-Escobar A, Patiño-López G, Penner R, Sumoza-Toledo A
Human Immunology 83(8-9):645-655 (2022)
DOI: 10.1016/j.humimm.2022.05.002 PMID: 35660323

Interferon gamma upregulates the cytokine receptors IFNGR1 and TNFRSF1A in HT-29-MTX E12 cells

Johnson BE, Panek P, Yu A, Fischer E, Koba M, Mendoza Hermosillo D, Capaldo CT
Cytokine 156:155892 (2022)
DOI: 101016/jcyto2022155892 PMID: 35653895 PMCID: PMC9636846/

Spirovetivane- and Eudesmane-Type Sesquiterpenoids isolated from the culture media of two cyanobacterial strains

O’Donnell TJ, Luo Y, Yoshida WY, Suzuki S, Sun R, Williams PG
Journal of Natural Products 85(2):415-425 (2022)
DOI: 10.1021/acs.jnatprod.1c01014 PMID: 35142496

Modulators of TRPM7 and its potential as a drug target for brain tumours

Ji D, Fleig A, Horgen FD, Feng ZP, Sun HS
Cell Calcium 101, 192521 (2022)
DOI: 10.1016/j.ceca.2021.102521 PMID: 34953296

Real-time optical analysis of a colorimetric LAMP assay for SARS-CoV-2 in saliva with a handheld instrument improves accuracy compared with endpoint assessment

Diaz LM, Johnson BE, Jenkins DM
Journal of Biomolecular Techniques 32, 158-171 (2021)
DOI: 10.7171/jbt.21-3203-011 PMID: 35027873 PMCID: PMC8730521

Transient Receptor Potential C 1/4/5 is a determinant of MTI-101 induced calcium influx and cell death in multiple myeloma

Elzamzamy OM, Johnson BE, Chen W-C, Hu G, Penner R, Hazlehurst LA
Cells 10, 1490 (2021)
DOI: 103390/cells10061490 PMID: 34199280 PMCID: PMC8231892

Role of TRPM7 kinase in cancer

Meng S, Alanazi R, Ji D, Bandura J, Luo ZW, Fleig A, Feng ZP, Sun HS
Cell Calcium 96:102400 (2021)
DOI: 10.1016/j.ceca.2021.102400 PMID: 33784560

Inhibition of TRPM7 with waixenicin A reduces glioblastoma cellular functions

Wong R, Gong H, Alanazi R, Bondoc A, Luck A, Sabha N, Horgen FD, Fleig A, Rutka JT, Feng ZP, Sun HS
Cell Calcium 92:102307 (2020)
DOI: 10.1016/j.ceca.2020.102307 PMID: 33080445

Waixenicin A, a marine-derived TRPM7 inhibitor: a promising CNS drug lead

Sun HS, Horgen FD, Romo D, Hull KG, Kiledal SA, Fleig A, Feng ZP
Acta Pharmacologica Sinica 41(12):1519-1524 (2020)
DOI: 101038/s41401-020-00512-4 PMID: 32994545

TRPM7 mediates neuronal cell death upstream of calcium/calmodulin-dependent protein kinase II and calcineurin mechanism in neonatal hypoxic-ischemic brain injury

Turlova E, Wong R, Xu B, Li F, Du L, Habbous S, Horgen FD, Fleig A Feng ZP, Sun HS
Translational Stroke Research 12(1):164-184 (2020)
DOI: 101007/s12975-020-00810-3 PMID: 32430797

Divalent cation influx and calcium homeostasis in germinal vesicle mouse oocytes

Ardestani G, Mehregan A, Fleig A, Horgen FD, Carvacho I, Fissore RA
Cell Calcium 87, 102181 (2020)
DOI: 10.1016/j.ceca.2020.102181 PMID: 32097818 PMCID: PMC7153984

TRPM7 contributes to progressive nephropathy

Suzuki S, Penner R, Fleig A
Scientific Reports 10, 2333 (2020)
DOI: 101038/s41598-020-59355-y PMID: 32047249 PMCID: PMC7012919

The role of TRPC1 in modulating cancer progression

Elzamzamy OM, Penner R, Hazlehurst LA
Cells 9, 388 (2020)
DOI: 103390/cells9020388 PMID: 32046188 PMCID: PMC7072717

Ca2+ homeostasis and Cancer

Gautier M, Trebak M, Fleig A, Vandier C, Ouadid-Ahidouch H
Cell Calcium 84, 102084 (2019)
DOI: 10.1016/j.ceca.2019.102084 PMID: 31593838

Ca2+ channels in Cancer

Gautier M, Trebak M, Fleig A, Vandier C, Ouadid-Ahidouch H
Cell Calcium 84, 102083 (2019)
DOI: 10.1016/j.ceca.2019.102083 PMID: 31606459

Pharmacology of JNJ-28583113: A novel TRPM2 antagonist

Fourgeaud L, Dvorak C, Faouzi M, Starkus J, Sahdeo S, Wang Q, Lord B, Coate H, Taylor N, He Y, Qin N, Wickenden A, Carruthers N, Lovenberg TW, Penner R, Bhattacharya A
European Journal of Pharmacology 853, 299-307 (2019)
DOI: 10.1016/j.ejphar.2019.03.043 PMID: 30965058

Areca nut extracts mobilize calcium and release pro-inflammatory cytokines from various immune cells<

Faouzi M, Neupane RP, Yang J, Williams P, Penner R
Scientific Reports 8(1), 1075 (2018)
DOI: 101038/s41598-017-18996-2 PMID: 29348572 PMCID: PMC5773534

TRPM7 channels play a role in high glucose-induced endoplasmic reticulum stress and neuronal cell apoptosis

Huang Y, Leng T-D, Inoue K, Yang T, Liu M, Horgen FD, Fleig A, Li J, Xiong Z-G
The Journal of Biological Chemistry 293(37), 14393-14406 (2018)
DOI: 10.1074/jbc.RA117.001032 PMID: 30076216 PMCID: PMC6139551

The TRPM7 kinase limits receptor-induced calcium release by regulating heterotrimeric G-proteins

Suzuki S, Lis A, Schmitz C, Penner R, Fleig A
Cellular and Molecular Life Sciences: CMLS 75(16), 3069-3078 (2018)
DOI: 101007/s00018-018-2786-z PMID: 29500477 PMCID: PMC6033657

The TRPM7 channel kinase regulates store-operated calcium entry

Faouzi M, Kilch T, Horgen FD, Fleig A, Penner R
The Journal of Physiology 595(10), 3165-3180 (2017)
DOI: 101113/JP274006 PMID: 28130783 PMCID: PMC5430208

New insights into Ca2+ channel function in health and disease

Fleig A, Parekh AB
The Journal of Physiology 595(10), 2997-2998 (2017)
DOI: 101113/JP274289 PMID: 28503825 PMCID: PMC5430230

Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice

Huang J, Furuya H, Faouzi M, Zhang Z, Monteilh-Zoller M, Kawabata KG, Horgen FD, Kawamori T, Penner R, Fleig A
Cell Communication and Signaling: CCS 15(1), 30 (2017)
DOI: 101186/s12964-017-0187-9 PMID: 28810912 PMCID: PMC5558780

Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion

Sisquella X, Nebl T, Thompson JK, Whitehead L, Malpede BM, Salinas ND, Rogers K, Tolia NH, Fleig A, O’Neill J, Tham W-H, Horgen, FD, Cowman AF
ELife 6:e21083 (2017)
DOI: 10.7554/eLife.21083 PMID: 28226242 PMCID: PMC5333951

Scalaradial Is a potent inhibitor of Transient Receptor Potential Melastatin 2 (TRPM2) ion channels

Starkus JG, Poerzgen P, Layugan K, Kawabata KG, Goto J-I, Suzuki S, Myers G, Kelly M, Penner R, Fleig A, Horgen FD
Journal of Natural Products 80(10), 2741-2750 (2017)
DOI: 10.1021/acs.jnatprod.7b00515 PMID: 29019677 PMCID: PMC6687308

The coiled-coil domain of zebrafish TRPM7 regulates Mg·nucleotide sensitivity

Jansen C, Sahni J, Suzuki S, Horgen FD, Penner R, Fleig A
Scientific Reports 6, 33459 (2016)
DOI: 101038/srep33459 PMID: 27628598 PMCID: PMC5024298

Human CNNM2 is not a Mg2+ transporter per se

Sponder G, Mastrototaro L, Kurth K, Merolle L, Zhang Z, Abdulhanan N, Smorodchenko A, Wolf K, Fleig A, Penner R, Iotti S, Aschenbach JR, Vormann J, Kolisek M
Pflugers Archiv: European Journal of Physiology 468(7), 1223-1240 (2016)
DOI: 101007/s00424-016-1816-7 PMID: 27068403

TRPM7 regulates axonal outgrowth and maturation of primary hippocampal neurons

Turlova E, Bae C YJ, Deurloo M, Chen W, Barszczyk A, Horgen FD, Fleig A, Feng Z-P, Sun H-S
Molecular Neurobiology 53(1), 595-610 (2016)
DOI: 101007/s12035-014-9032-y PMID: 25502295 PMCID: PMC4820394

TRPM7 kinase activity regulates murine mast cell degranulation

Zierler S, Sumoza-Toledo A, Suzuki S, Dúill FÓ, Ryazanova LV, Penner R, Ryazanov AG, Fleig A
The Journal of Physiology 594(11), 2957-2970 (2016)
DOI: 101113/JP271564 PMID: 26660477 PMCID: PMC4887679

State-dependent blocking mechanism of Kv13 channels by the antimycobacterial drug clofazimine

Faouzi M, Starkus JG, Penner R
British Journal of Pharmacology 172(21), 5161-5173 (2015)
DOI: 10.1111/bph.13283 PMID: 26276903 PMCID: PMC4687807

Small-conductance Ca2+-activated potassium type 2 channels regulate the formation of contextual fear memory

Murthy SRK, Sherrin T, Jansen C, Nijholt I, Robles M, Dolga AM, Andreotti N, Sabatier J-M, Knaus H-G, Penner R, Todorovic C, Blank T
PloS One 10(5), e0127264 (2015)
DOI: 10.1371/journal.pone.0127264 PMID: 25938421 PMCID: PMC4418695

Regulation of endogenous and heterologous Ca2+ release-activated Ca2+ currents by pH

Beck A, Fleig A, Penner R, Peinelt C
Cell Calcium 56(3), 235-243 (2014)
DOI: 10.1016/j.ceca.2014.07.011 PMID: 25168908 PMCID: PMC4162834

TRPM2

Faouzi M, Penner R
Handbook of Experimental Pharmacology 222, 403-426 (2014)
DOI: 101007/978-3-642-54215-2_16 PMID: 24756715

TRPM7

Fleig A, Chubanov V
Handbook of Experimental Pharmacology 222, 521-546 (2014)
DOI: 101007/978-3-642-54215-2_21 PMID: 24756720 PMCID: PMC5663634

Elucidating the role of the TRPM7 alpha-kinase: TRPM7 kinase inactivation leads to magnesium deprivation resistance phenotype in mice

Ryazanova LV, Hu Z, Suzuki S, Chubanov V, Fleig A, Ryazanov AG
Scientific Reports 4, 7599 (2014)
DOI: 101038/srep07599 PMID: 25534891 PMCID: PMC4274504

N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation

Zhang Z, Faouzi M, Huang J, Geerts D, Yu H, Fleig A, Penner R
Oncotarget 5(17), 7625-7634 (2014)
DOI: 10.18632/oncotarget.2283 PMID: 25277194 PMCID: PMC4202149

The TRPM6 kinase domain determines the Mg·ATP sensitivity of TRPM7/M6 heteromeric ion channels

Zhang Z, Yu H, Huang J, Faouzi M, Schmitz C, Penner R, Fleig, A
The Journal of Biological Chemistry 289(8), 5217-5227 (2014)
DOI: 10.1074/jbc.M113.512285 PMID: 24385424 PMCID: PMC3931078

ORAI3 silencing alters cell proliferation and cell cycle progression via c-myc pathway in breast cancer cells

Faouzi M, Kischel P, Hague F, Ahidouch A, Benzerdjeb N, Sevestre H, Penner R, Ouadid-Ahidouch H
Biochimica et Biophysica Acta 1833(3), 752-760 (2013)
DOI: 10.1016/j.bbamcr.2012.12.009 PMID: 23266555

Solute Carrier Family SLC41, what do we really know about it?

Fleig A, Schweigel-Röntgen M, Kolisek M
Wiley Interdisciplinary Reviews Membrane Transport and Signaling 2(6) (2013)
DOI: 10.1002/wmts.95 PMID: 24340240 PMCID: PMC3855994

TRPM2 channels are not required for acute airway inflammation in OVA-induced severe allergic asthma in mice

Sumoza-Toledo A, Fleig A, Penner R
Journal of Inflammation (London, England) 10(1), 19 (2013)
DOI: 101186/1476-9255-10-19 PMID: 23631390 PMCID: PMC3648402

STIM2 drives Ca2+ oscillations through store-operated Ca2+ entry caused by mild store depletion

Thiel M, Lis A, Penner R
The Journal of Physiology 591(Pt 6), 1433-1445 (2013)
DOI: 10.1113/jphysiol.2012.245399 PMID: 23359669 PMCID: PMC3607164

TRPM7 triggers Ca2+ sparks and invadosome formation in neuroblastoma cells

Visser D, Langeslag M, Kedziora KM, Klarenbeek J, Kamermans A, Horgen FD, Fleig A, van Leeuwen FN, Jalink K
Cell Calcium 54(6), 404-415 (2013)
DOI: 10.1016/j.ceca.2013.09.003 PMID: 24176224 PMCID: PMC4912378

TRPM7 is regulated by halides through its kinase domain

Yu H, Zhang Z, Lis A, Penner R, Fleig A
Cellular and Molecular Life Sciences: CMLS 70(15):2757-2771 (2013)
DOI: 101007/s00018-013-1284-6 PMID: 23471296 PMCID: PMC3710292

Stimulation of Ca2+ channel Orai1/STIM1 by serum- and glucocorticoid-inducible kinase 1 (SGK1)

Eylenstein A, Gehring E-M, Heise N, Shumilina E, Schmidt S, Szteyn K, Münzer P, Nurbaeva MK, Eichenmüller M, Tyan L, Regel I, Föller, M, Kuhl D, Soboloff J, Penner R, Lang F
The FASEB Journal 25(6), 2012-2021 (2011)
DOI: 10.1096/fj.10-178210 PMID: 21385992 PMCID: PMC3999400

Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release

Sumoza-Toledo A, Lange I, Cortado H, Bhagat H, Mori Y, Fleig A, Penner R, Partida-Sánchez S
The FASEB Journal 25(10), 3529-3542 (2011)
DOI: 10.1096/fj.10-178483 PMID: 21753080 PMCID: PMC3177582

TRPM2: A multifunctional ion channel for calcium signaling

Sumoza-Toledo A, Penner R
The Journal of Physiology 589(Pt 7), 1515-1525 (2011)
DOI: 10.1113/jphysiol.2010.201855 PMID: 21135052 PMCID: PMC3099011

Waixenicin A inhibits cell proliferation through magnesium-dependent block of Transient Receptor Potential Melastatin 7 (TRPM7) channels

Zierler S, Yao G, Zhang Z, Kuo WC, Pörzgen P, Penner R, Horgen FD, Fleig A
The Journal of Biological Chemistry 286(45), 39328-39335 (2011)
DOI: 10.1074/jbc.M111.264341 PMID: 21926172 PMCID: PMC3234757

TRPM5 regulates glucose-stimulated insulin secretion

Brixel LR, Monteilh-Zoller MK, Ingenbrandt CS, Fleig A, Penner R, Enklaar T, Zabel BU, Prawitt D
Pflügers Archiv: European Journal of Physiology 460(1), 69-76 (2010)
DOI: 101007/s00424-010-0835-z PMID: 20393858 PMCID: PMC5663632

Development and optimization of a high-throughput bioassay for TRPM7 ion channel inhibitors

Castillo B, Pörzgen P, Penner R, Horgen FD, Fleig A
Journal of Biomolecular Screening 15(5), 498-507 (2010)
DOI: 101177/1087057110368294 PMID: 20413646 PMCID: PMC4725312

Two novel 2-aminoethyl diphenylborinate (2-APB) analogues differentially activate and inhibit store-operated Ca2+ entry via STIM proteins

Goto J-I, Suzuki AZ, Ozaki S, Matsumoto N, Nakamura T, Ebisui E, Fleig A, Penner R, Mikoshiba K
Cell Calcium 47(1), 1-10 (2010)
DOI: 10.1016/j.ceca.2009.10.004 PMID: 19945161 PMCID: PMC2905153

Activation of store-operated ICRAC by hydrogen peroxide

Grupe M, Myers G, Penner R, Fleig A
Cell Calcium 48(1), 1-9 (2010)
DOI: 101016/jceca201005005 PMID: 20646759 PMCID: PMC2929316

A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating

Lis A, Zierler S, Peinelt C, Fleig A, Penner R
The Journal of General Physiology 136(6), 673-686 (2010)
DOI: 10.1085/jgp.201010484 PMID: 21115697 PMCID: PMC2995155

TRPM7 is essential for Mg2+ homeostasis in mammals

Ryazanova LV, Rondon LJ, Zierler S, Hu Z, Galli J, Yamaguchi TP, Mazur A, Fleig A, Ryazanov AG
Nature Communications 1, 109 (2010)
DOI: 101038/ncomms1108 PMID: 21045827 PMCID: PMC3060619

The calcium-permeable non-selective cation channel TRPM2 is modulated by cellular acidification

Starkus JG, Fleig A, Penner R
The Journal of Physiology 588(Pt 8), 1227-1240 (2010)
DOI: 10.1113/jphysiol.2010.187476 PMID: 20194125 PMCID: PMC2872729

TRPM2 functions as a lysosomal Ca2+-release channel in beta cells

Lange I, Yamamoto S, Partida-Sanchez S, Mori Y, Fleig A, Penner R
Science Signaling 2(71), ra23 (2009)
DOI: 10.1126/scisignal.2000278 PMID: 19454650 PMCID: PMC2779714

IP3 receptor subtype-dependent activation of store-operated calcium entry through ICRAC

Peinelt C, Beck A, Monteilh-Zoller MK, Penner R, Fleig A
Cell Calcium 45(4), 326-330 (2009)
DOI: 10.1016/j.ceca.2008.12.001 PMID: 19157540 PMCID: PMC2744131

Lipopolysaccharide-induced down-regulation of Ca2+ release-activated Ca2+ currents (ICRAC) but not Ca2+-activated TRPM4-like currents (ICAN) in cultured mouse microglial cells

Beck A, Penner R, Fleig A
The Journal of Physiology 586(2), 427-439 (2008)
DOI: 10.1113/jphysiol.2007.145151 PMID: 17991695 PMCID: PMC2375604

SLC41A1 is a novel mammalian Mg2+ carrier

Kolisek M, Launay P, Beck A, Sponder G, Serafini N, Brenkus M, Froschauer EM, Martens H, Fleig A, Schweigel M
The Journal of Biological Chemistry 283(23), 16235-16247 (2008)
DOI: 10.1074/jbc.M707276200 PMID: 18367447 PMCID: PMC2414286

Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils

Lange I, Penner R, Fleig A, Beck A
Cell Calcium 44(6), 604-615 (2008)
DOI: 10.1016/j.ceca.2008.05.001 PMID: 18572241 PMCID: PMC2597220

STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation

Parvez S, Beck A, Peinelt C, Soboloff J, Lis A, Monteilh-Zoller M, Gill DL, Fleig A, Penner R
The FASEB Journal 22(3), 752-761 (2008)
DOI: 10.1096/fj.07-9449com PMID: 17905723 PMCID: PMC3601890

2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels

Peinelt C, Lis A, Beck A, Fleig A, Penner R
The Journal of Physiology 586(13), 3061-3073 (2008)
DOI: 10.1113/jphysiol.2008.151365 PMID: 18403424 PMCID: PMC2538778

Clofazimine inhibits human Kv13 potassium channel by perturbing calcium oscillation in T lymphocytes

Ren YR, Pan F, Parvez S, Fleig A, Chong CR, Xu J, Dang Y, Zhang J, Jiang H, Penner R, Liu JO
PloS One 3(12), e4009 (2008)
DOI: 10.1371/journal.pone.0004009 PMID: 19104661 PMCID: PMC2602975

TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

Yamamoto S, Shimizu S, Kiyonaka S, Takahashi N, Wajima T, Hara Y, Negoro T, Hiroi T, Kiuchi Y, Okada T, Kaneko S, Lange I, Fleig A, Penner R, Nishi M, Takeshima H, Mori Y
Nature Medicine 14(7), 738-747 (2008)
DOI: 101038/nm1758 PMID: 18542050 PMCID: PMC2789807

TRPM7 channel is sensitive to osmotic gradients in human kidney cells

Bessac BF, Fleig, A
The Journal of Physiology 582(Pt 3), 1073-1086 (2007)
DOI: 10.1113/jphysiol.2007.130534 PMID: 17510191 PMCID: PMC2075261

TRPM4 controls insulin secretion in pancreatic β-cells

Cheng H, Beck A, Launay P, Gross SA, Stokes AJ, Kinet J-P, Fleig A, Penner R
Cell Calcium 41(1), 51-61 (2007)
DOI: 10.1016/j.ceca.2006.04.032 PMID: 16806463 PMCID: PMC5663640

CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties

Lis A, Peinelt C, Beck A, Parvez S, Monteilh-Zoller M, Fleig A, Penner R
Current Biology 17(9), 794-800 (2007)
DOI: 10.1016/j.cub.2007.03.065 PMID: 17442569 PMCID: PMC5663639

The Mg2+ and Mg2+-nucleotide-regulated channel-kinase TRPM7

Penner R, Fleig A
Handbook of Experimental Pharmacology 179(179), 313-328 (2007)
DOI: 101007/978-3-540-34891-7_19 PMID: 17217066 PMCID: PMC5663631

Regulation of TRPM2 by extra- and intracellular calcium

Starkus JG, Beck A, Fleig A, Penner R
The Journal of General Physiology 130(4), 427-440 (2007)
DOI: 10.1085/jgp.200709836 PMID: 17893195 PMCID: PMC2151648

Cell cycle-dependent regulation of store-operated ICRAC and Mg2+-nucleotide-regulated MagNuM (TRPM7) currents

Tani D, Monteilh-Zoller MK, Fleig A, Penner R
Cell Calcium 41(3), 249-260 (2007)
DOI: 10.1016/j.ceca.2006.07.004 PMID: 17064762 PMCID: PMC5663638

Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes

Beck A, Kolisek M, Bagley LA, Fleig A, Penner R
The FASEB Journal 20(7), 962-964 (2006)
DOI: 10.1096/fj.05-5538fje PMID: 16585058

TRPM7 channel is regulated by magnesium nucleotides via its kinase domain

Demeuse P, Penner R, Fleig A
The Journal of General Physiology 127(4), 421-434 (2006)
DOI: 10.1085/jgp.200509410 PMID: 16533898 PMCID: PMC2151514

Amplification of CRAC current by STIM1 and CRACM1 (Orai1)

Peinelt C, Vig M, Koomoa DL, Beck A, Nadler MJS, Koblan-Huberson M, Lis A, Fleig A, Penner R, Kinet J-P
Nature Cell Biology 8(7), 771-773 (2006)
DOI: 101038/ncb1435 PMID: 16733527 PMCID: PMC5685802

TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD

Stokes AJ, Wakano C, Koblan-Huberson M, Adra CN, Fleig A, Turner HC
Cellular Signalling 18(10), 1584-1594 (2006)
DOI: 10.1016/j.cellsig.2005.12.009 PMID: 16500080

A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity

Takezawa R, Cheng H, Beck A, Ishikawa J, Launay P, Kubota H, Kinet J-P, Fleig A, Yamada T, Penner R
Molecular Pharmacology 69(4), 1413-1420 (2006)
DOI: 10.1124/mol.105.021154 PMID: 16407466

CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry

Vig M, Peinelt C, Beck A, Koomoa DL, Rabah D, Koblan-Huberson M, Kraft S, Turner HC, Fleig A, Penner R, & Kinet J-P
Science 312(5777), 1220-1223 (2006)
DOI: 10.1126/science.1127883 PMID: 16645049 PMCID: PMC5685805

CRACM1 multimers form the ion-selective pore of the CRAC channel

Vig M, Beck A, Billingsley JM, Lis A, Parvez S, Peinelt C, Koomoa DL, Soboloff J, Gill DL, Fleig A, Kinet J-P, Penner, R
Current Biology 16(20), 2073-2079 (2006)
DOI: 10.1016/j.cub.2006.08.085 PMID: 16978865 PMCID: PMC5685803

Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels

Kolisek M, Beck A, Fleig A, Penner R
Molecular Cell 18(1), 61-69 (2005)
DOI: 10.1016/j.molcel.2005.02.033 PMID: 15808509

Emerging roles of TRPM channels

Fleig A, Penner R
Novartis Foundation Symposium 258, 248-258; discussion 258-266 (2004)
PMID: 15104187

The TRPM ion channel subfamily: Molecular, biophysical and functional features

Fleig A, Penner R
Trends in Pharmacological Sciences 25(12), 633-639 (2004)
DOI: 10.1016/j.tips.2004.10.004 PMID: 15530641

D-6-Deoxy-myo-inositol 1,3,4,5-tetrakisphosphate, a mimic of d-myo-inositol 1,3,4,5-tetrakisphosphate: Biological activity and pH-dependent conformational properties

Horne G, Maechling C, Fleig A, Hirata M, Penner R, Spiess B, Potter BVL
Biochemical and Biophysical Research Communications 320(4), 1262-1270 (2004)
DOI: 10.1016/j.bbrc.2004.06.079 PMID: 15249226

TRPM4 regulates calcium oscillations after T cell activation

Launay P, Cheng H, Srivatsan S, Penner R, Fleig A, Kinet J-P
Science 306(5700), 1374-1377 (2004)
DOI: 10.1126/science.1098845 PMID: 15550671

Store-operated calcium entry: A tough nut to CRAC

Penner R, Fleig A
Science’s STKE: Signal Transduction Knowledge Environment 2004(243), pe38 (2004)
DOI: 10.1126/stke.2432004pe38 PMID: 15280580

Dual-function ion channel/protein kinases: Novel components of vertebrate magnesium regulatory mechanisms

Schmitz C, Perraud A-L, Fleig A, Scharenberg AM
Pediatric Research 55(5), 734-737 (2004)
DOI: 10.1203/01.PDR.0000117848.37520.A2 PMID: 14764909

Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain

Takezawa R, Schmitz C, Demeuse P, Scharenberg AM, Penner R, Fleig A
Proceedings of the National Academy of Sciences of the United States of America 101(16), 6009-6014 (2004)
DOI: 10.1073/pnas.0307565101 PMID: 15069188 PMCID: PMC395914

TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions

Monteilh-Zoller MK, Hermosura MC, Nadler MJS, Scharenberg AM, Penner R, Fleig A
The Journal of General Physiology 121(1), 49-60 (2003)
DOI: 10.1085/jgp.20028740 PMID: 12508053 PMCID: PMC2217320

TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i

Prawitt D, Monteilh-Zoller MK, Brixel L, Spangenberg C, Zabel B, Fleig A, Penner R
Proceedings of the National Academy of Sciences of the United States of America 100(25), 15166-15171 (2003)
DOI: 10.1073/pnas.2334624100 PMID: 14634208 PMCID: PMC299937

Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7

Schmitz C, Perraud A-L, Johnson C O, Inabe K, Smith MK, Penner R, Kurosaki T, Fleig A, Scharenberg AM
Cell 114(2), 191-200 (2003)
DOI: 101016/s0092-8674(03)00556-7 PMID: 12887921

Discrimination of intracellular calcium store subcompartments using TRPV1 (Transient Receptor Potential Channel, Vanilloid subfamily member 1) release channel activity

Turner HC, Fleig A, Stokes AJ, Kinet J-P, Penner R
The Biochemical Journal 371(Pt 2), 341-350 (2003)
DOI: 101042/BJ20021381 PMID: 12513687 PMCID: PMC1223279

Dissociation of the store-operated calcium current ICRAC and the Mg-nucleotide-regulated metal ion current MagNuM

Hermosura MC, Monteilh-Zoller MK, Scharenberg AM, Penner R, Fleig A
The Journal of Physiology 539(Pt 2), 445-458 (2002)
DOI: 10.1113/jphysiol.2001.013361 PMID: 11882677 PMCID: PMC2290162

TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization

Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, Kinet J P
Cell 109(3), 397-407 (2002)
DOI: 101016/s0092-8674(02)00719-5 PMID: 12015988

A unified nomenclature for the superfamily of TRP cation channels

Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, Schultz G, Shimizu N, Zhu MX
Molecular Cell 9(2), 229-231 (2002)
DOI: 101016/S1097-2765(02)00448-3 PMID: 11864597

Transient receptor potential 1 regulates capacitative Ca2+ entry and Ca2+ release from endoplasmic reticulum in B lymphocytes

Mori Y, Wakamori M, Miyakawa T, Hermosura M, Hara Y, Nishida M, Hirose K, Mizushima A, Kurosaki M, Mori E, Gotoh K, Okada T, Fleig A, Penner R, Iino M, Kurosaki T
The Journal of Experimental Medicine 195(6), 673-681 (2002)
DOI: 10.1084/jem.20011758 PMID: 11901194 PMCID: PMC2193746

LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability

Nadler MJS, Hermosura MC, Inabe K, Perraud A-L, Zhu Q, Stokes AJ, Kurosaki T, Kinet J-P, Penner R, Scharenberg AM, Fleig, A
Nature 411(6837), 590-595 (2001)
DOI: 101038/35079092 PMID: 11385574

ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology

Perraud A-L, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, Stokes AJ, Zhu Q, Bessman MJ, Penner R, Kinet J-P, Scharenberg AM
Nature 411(6837), 595-599 (2001)
DOI: 101038/35079100 PMID: 11385575

CaT1 and the calcium release-activated calcium channel manifest distinct pore properties

Voets T, Prenen J, Fleig A, Vennekens R, Watanabe H, Hoenderop JG, Bindels RJ, Droogmans G, Penner R, Nilius B
The Journal of Biological Chemistry 276(51), 47767-47770 (2001)
DOI: 10.1074/jbc.C100607200 PMID: 11687570

Hearing threshold and frequency discrimination in the purely aquatic frog Xenopus laevis (Pipidae): Measurement by means of conditioning

Elepfandt A, Eistetter I, Fleig A, Günther E, Hainich M, Hepperle S, Traub B
The Journal of Experimental Biology 203(Pt 23), 3621-3629 (2000)
DOI: 10.1242/jeb.203.23.3621 PMID: 11060223

InsP4 facilitates store-operated calcium influx by inhibition of InsP3 5-phosphatase

Hermosura MC, Takeuchi H, Fleig A, Riley AM, Potter BV, Hirata M, Penner R
Nature 408(6813), 735-740 (2000)
DOI: 101038/35047115 PMID: 11130077

Previous Publications

Differential modulation of voltage-dependent Ca2+ currents by EGTA and BAPTA in bovine adrenal chromaffin cells

Bödding M, Penner R
Pflugers Archiv: European Journal of Physiology 439(1-2), 27-38 (1999)
DOI: 101007/s004249900158 PMID: 10650997

Calcium release-activated calcium current (ICRAC) is a direct target for sphingosine

Mathes C, Fleig A, Penner R
The Journal of Biological Chemistry 273(39), 25020-25030 (1998)
DOI: 10.1074/jbc.273.39.25020 PMID: 9737958

Near-visible ultraviolet light induces a novel ubiquitous calcium-permeable cation current in mammalian cell lines

Mendez F, Penner R
The Journal of Physiology 507 ( Pt 2), 365-377 (1998)
DOI: 10.1111/j.1469-7793.1998.365bt.x PMID: 9518699 PMCID: PMC2230791

The store-operated calcium current ICRAC: Nonlinear activation by InsP3 and dissociation from calcium release

Parekh AB, Fleig A, Penner R
Cell 89(6), 973-980 (1997)
DOI: 101016/s0092-8674(00)80282-2 PMID: 9200615

Effects of clamp rise-time on rat brain IIA sodium channels in Xenopus oocytes

Ruben PC, Fleig A, Featherstone D, Starkus JG, Rayner MD
Journal of Neuroscience Methods 73(2), 113-122 (1997)
DOI: 101016/s0165-0270(96)02216-9 PMID: 9196281

Store depletion and calcium influx

Parekh AB, Penner R
Physiological Reviews 77(4), 901-930 (1997)
DOI: 10.1152/physrev.1997.77.4.901 PMID: 9354808

Ca2+-induced Ca2+ release in Chinese hamster ovary (CHO) cells co-expressing dihydropyridine and ryanodine receptors

Suda N, Franzius D, Fleig A, Nishimura S, Bödding M, Hoth M, Takeshima H, Penner R
The Journal of General Physiology 109(5), 619-631 (1997)
DOI: 10.1085/jgp.109.5.619 PMID: 9154908 PMCID: PMC2217062

Acceleration of membrane recycling by axotomy of cultured Aplysia neurons

Ashery U, Penner R, Spira ME
Neuron 16(3), 641-651 (1996)
DOI: 101016/s0896-6273(00)80083-5 PMID: 8785061

Silent calcium channels generate excessive tail currents and facilitation of calcium currents in rat skeletal myoballs

Fleig A, Penner R
The Journal of Physiology 494 ( Pt 1), 141-153 (1996)
DOI: 10.1113/jphysiol.1996.sp021481 PMID: 8814612 PMCID: PMC1160620

Absence of Ca2+ current facilitation in skeletal muscle of transgenic mice lacking the type 1 ryanodine receptor

Fleig A, Takeshima H, Penner R
The Journal of Physiology 496 ( Pt 2), 339-345 (1996)
DOI: 10.1113/jphysiol.1996.sp021689 PMID: 8910220 PMCID: PMC1160881

Regulation of store-operated calcium currents in mast cells

Parekh AB, Penner R
Society of General Physiologists Series 51, 231-239 (1996)
PMID: 8809947

Characterization of the Ca2+ current in isolated terminals of crustacean peptidergic neurons

Richmond JE, Penner R, Keller R, Cooke IM
The Journal of Experimental Biology 199(Pt 9), 2053-2059 (1996)
DOI: 10.1242/jeb.199.9.2053 PMID: 8831146

Excessive repolarization-dependent calcium currents induced by strong depolarizations in rat skeletal myoballs

Fleig A, Penner R
The Journal of Physiology 489 ( Pt 1), 41-53 (1995)
DOI: 10.1113/jphysiol.1995.sp021028 PMID: 8583414 PMCID: PMC1156790

Activation of store-operated calcium influx at resting InsP3 levels by sensitization of the InsP3 receptor in rat basophilic leukaemia cells

Parekh AB, Penner R
The Journal of Physiology 489 ( Pt 2), 377-382 (1995)
DOI: 10.1113/jphysiol.1995.sp021058 PMID: 8847633 PMCID: PMC1156765

Depletion-activated calcium current is inhibited by protein kinase in RBL-2H3 cells

Parekh AB, Penner R
Proceedings of the National Academy of Sciences of the United States of America 92(17), 7907-7911 (1995)
DOI: 10.1073/pnas.92.17.7907 PMID: 7644512 PMCID: PMC41255

A Practical Guide to Patch Clamping

Penner R
Single-Channel Recording, Second Edition, eds. Sakmann B, Neher E. Plenum Press, New York, pp 3-30 (1995)
DOI: 10.1007/978-1-4419-1229-9_1

Non-specific effects of calcium entry antagonists in mast cells

Franzius D, Hoth M, Penner R
Pflugers Archiv: European Journal of Physiology 428(5-6), 433-438 (1994)
DOI: 101007/bf00374562 PMID: 7838664

Mice sans synaptotagmin

Neher E, Penner R
Nature 372(6504), 316-317 (1994)
DOI: 101038/372316a0 PMID: 7969483

Membrane repolarization stops caffeine-induced Ca2+ release in skeletal muscle cells

Suda N, Penner R
Proceedings of the National Academy of Sciences of the United States of America 91(12), 5725-5729 (1994)
DOI: 10.1073/pnas.91.12.5725 PMID: 8202554 PMCID: PMC44069

Kinetic mode switch of rat brain IIA Na channels in Xenopus oocytes excised macropatches

Fleig A, Ruben PC, Rayner MD
Pflügers Archiv: European Journal of Physiology 427(5-6), 399-405 (1994)
DOI: 101007/bf00374253 PMID: 797113

Point mutations in IIS4 alter activation and inactivation of rat brain IIA Na channels in Xenopus oocyte macropatches

Fleig A, Fitch JM, Goldin AL, Rayner MD, Starkus JG, Ruben PC
Pflügers Archiv: European Journal of Physiology 427(5-6), 406-413 (1994)
DOI: 101007/BF00374254 PMID: 7971139

Fast and slow inactivation of sodium channels: Effects of photodynamic modification by methylene blue

Starkus JG, Rayner MD, Fleig A, Ruben PC
Biophysical Journal 65(2), 715-726 (1993)
DOI: 101016/S0006-3495(93)81098-1 PMID: 821889 PMCID: PMC1225774

Ca2+ and Mn2+ influx through receptor-mediated activation of nonspecific cation channels in mast cells

Fasolato C, Hoth M, Matthews G, Penner R
Proceedings of the National Academy of Sciences of the United States of America 90(7), 3068-3072 (1993)
DOI: 10.1073/pnas.90.7.3068 PMID: 7681994 PMCID: PMC46238

A GTP-dependent step in the activation mechanism of capacitative calcium influx

Fasolato C, Hoth M, Penner R
The Journal of Biological Chemistry 268(28), 20737-20740 (1993)
PMID: 8407897

Multiple mechanisms of manganese-induced quenching of fura-2 fluorescence in rat mast cells

Fasolato C, Hoth M, Penner R
Pflugers Archiv: European Journal of Physiology 423(3-4), 225-231 (1993)
DOI: 101007/bf00374399 PMID: 8321625

Ion channels and calcium signaling in mast cells

Hoth M, Fasolato C, Penner R
Annals of the New York Academy of Sciences 707, 198-209 (1993)
DOI: 10.1111/j.1749-6632.1993.tb38053.x PMID: 9137553

Calcium release-activated calcium current in rat mast cells

Hoth M, Penner R
The Journal of Physiology 465, 359-386 (1993)
DOI: 10.1113/jphysiol.1993.sp019681 PMID: 8229840 PMCID: PMC1175434

Calcium influx and its control by calcium release

Penner R, Fasolato C, Hoth M
Current Opinion in Neurobiology 3(3), 368-374 (1993)
DOI: 101016/0959-4388(93)90130-q PMID: 8396477

Transfected cGMP-dependent protein kinase suppresses calcium transients by inhibition of inositol 1,4,5-trisphosphate production

Ruth P, Wang GX, Boekhoff I, May B, Pfeifer A, Penner R, Korth M, Breer H, Hofmann F
Proceedings of the National Academy of Sciences of the United States of America 90(7), 2623-2627 (1993)
DOI: 10.1073/pnas.90.7.2623 PMID: 8385340 PMCID: PMC46147

Depletion of intracellular calcium stores activates a calcium current in mast cells

Hoth M, Penner R
Nature 355(6358), 353-356 (1992)
DOI: 101038/355353a0 PMID: 1309940

Novel chloride conductance in the membrane of bovine chromaffin cells activated by intracellular GTP gamma S

Doroshenko P, Penner R, Neher, E
The Journal of Physiology 436, 711-724 (1991)
DOI: 10.1113/jphysiol.1991.sp018575 PMID: 1712041 PMCID: PMC1181530

Guanosine 5’-[beta-thio]triphosphate selectively activates calcium signaling in mast cells

von zur Mühlen F, Eckstein F, Penner R
Proceedings of the National Academy of Sciences of the United States of America 88(3), 926-930 (1991)
DOI: 10.1073/pnas.88.3.926 PMID: 1992486 PMCID: PMC50927

A GTP analogue induces calcium release but not secretion in rat mast cells

von zur Mühlen F, Penner R
International Archives of Allergy and Applied Immunology 94(1-4), 74-75 (1991)
DOI: 101159/000235329 PMID: 1657794

Effects of angiotensin II on intracellular calcium and electrical function of mouse renal juxtaglomerular cells

Kurtz A, Penner R
Kidney International Supplement 30, S51-54 (1990)
PMID: 2175372

Lack of direct evidence for a functional role of voltage-operated calcium channels in juxtaglomerular cells

Kurtz A, Skott O, Chegini S, Penner R
Pflugers Archiv: European Journal of Physiology 416(3), 281-287 (1990)
DOI: 101007/bf00392064 PMID: 2166274

Angiotensin II induces oscillations of intracellular calcium and blocks anomalous inward rectifying potassium current in mouse renal juxtaglomerular cells

Kurtz A, Penner R
Proceedings of the National Academy of Sciences of the United States of America 86(9), 3423-3427 (1989)
DOI: 10.1073/pnas.86.9.3423 PMID: 2541447 PMCID: PMC287145

Second messenger-activated calcium influx in rat peritoneal mast cells

Matthews G, Neher E, Penner R
The Journal of Physiology 418, 105-130 (1989)
DOI: 10.1113/jphysiol.1989.sp017830 PMID: 2559968 PMCID: PMC1189961

Chloride conductance activated by external agonists and internal messengers in rat peritoneal mast cells

Matthews G, Neher E, Penner R
The Journal of Physiology 418, 131-144 (1989)
DOI: 10.1113/jphysiol.1989.sp017831 PMID: 2559969 PMCID: PMC1189962

Stimulus-secretion coupling in mast cells

Penner R, Neher E
Society of General Physiologists Series 44, 295-310 (1989)
PMID: 2781355

[The importance of calcium for secretion in excitable and non-excitable cells]

Penner R, Neher E
Arzneimittel-Forschung 39(1A), 174-177 (1989)
PMID: 2655617

Regulation of calcium influx by second messengers in rat mast cells

Penner R, Matthews G, Neher E
Nature 334(6182), 499-504 (1988)
DOI: 101038/334499a0 PMID: 2457169

The role of calcium in stimulus-secretion coupling in excitable and non-excitable cells

Penner R, Neher E
The Journal of Experimental Biology 139, 329-345 (1988)
DOI: 10.1242/jeb.139.1.329 PMID: 2850338

Secretory responses of rat peritoneal mast cells to high intracellular calcium

Penner R, Neher E
FEBS Letters 226(2), 307-313 (1988)
DOI: 101016/0014-5793(88)81445-5 PMID: 3123272

Multiple signaling pathways control stimulus-secretion coupling in rat peritoneal mast cells

Penner R
Proceedings of the National Academy of Sciences of the United States of America 85(24), 9856-9860 (1988)
DOI: 10.1073/pnas.85.24.9856 PMID: 3059353 PMCID: PMC282880

Functional expression of the calcium release channel from skeletal muscle ryanodine receptor cDNA

Penner R, Neher E, Takeshima H, Nishimura S, Numa S
FEBS Letters 259(1), 217-221 (1989)
DOI: 101016/0014-5793(89)81532-7 PMID: 2557244

The patch-clamp technique in the study of secretion

Penner R, Neher E
Trends in Neurosciences 12(4), 159-163 (1989)
DOI: 101016/0166-2236(89)90059-3 PMID: 2470174

Differential effects of various secretagogues on quantal transmitter release from mouse motor nerve terminals treated with botulinum A and tetanus toxin

Dreyer F, Rosenberg F, Becker C, Bigalke H, Penner R
Naunyn-Schmiedeberg’s Archives of Pharmacology 335(1), 1-7 (1987)
DOI: 101007/bf00165027 PMID: 2883583

The actions of presynaptic snake toxins on membrane currents of mouse motor nerve terminals

Dreyer F, Penner R
The Journal of Physiology 386, 455-463 (1987)
DOI: 10.1113/jphysiol.1987.sp016544 PMID: 2445966 PMCID: PMC1192472

Distinct sites of action of clostridial neurotoxins revealed by double-poisoning of mouse motor nerve terminals

Gansel M, Penner R, Dreyer F
Pflugers Archiv: European Journal of Physiology 409(4-5), 533-539 (1987)
DOI: 101007/bf00583812 PMID: 2888074

Washout phenomena in dialyzed mast cells allow discrimination of different steps in stimulus-secretion coupling

Penner R, Pusch M, Neher E
Bioscience Reports 7(4), 313-321 (1987)
DOI: 101007/bf01121453 PMID: 2445392

Two different presynaptic calcium currents in mouse motor nerve terminals

Penner R, Dreyer F
Pflugers Archiv: European Journal of Physiology 406(2), 190-197 (1986)
DOI: 101007/bf00586682 PMID: 2421238

Intracellularly injected tetanus toxin inhibits exocytosis in bovine adrenal chromaffin cells

Penner R, Neher E, Dreyer F
Nature 324(6092), 76-78 (1986)
DOI: 101038/324076a0 PMID: 3785374

Dendrotoxin: A selective blocker of a non-inactivating potassium current in guinea-pig dorsal root ganglion neurones

Penner,R, Petersen,M, Pierau FK, Dreyer F
Pflugers Archiv: European Journal of Physiology 407(4), 365-369 (1986)
DOI: 101007/bf00652619 PMID: 2430257

Beta-bungarotoxin inhibits a non-inactivating potassium current in guinea pig dorsal root ganglion neurones

Petersen M, Penner R, Pierau FK, Dreyer F
Neuroscience Letters 68(1), 141-145 (1986)
DOI: 101016/0304-3940(86)90244-2 PMID: 2425306

Action of botulinum A toxin and tetanus toxin on synaptic transmission

Dreyer F, Becker C, Bigalke H, Funk J, Penner R, Rosenberg F, Ziegler M
Journal De Physiologie (Paris) 79(4), 252-258 (1984)
PMID: 6152293