The grant titled “TWEAK-Fn14 regulation of non-canonical NF-κB signaling in chronic renal inflammation,” will support the Ortega Lab for 3 years as the team focuses determining the role of non-canonical NF-κB signaling in promoting chronic cytokine pressure in response to kidney injury. Identifying proinflammatory features of chronic kidney disease can lay the foundation for novel therapeutic approaches that promote sustained kidney health and function.