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Drs. Sayuri Suzuki, Andrea Fleig, and colleagues identify the bioactive sites on waixenicin A that inhibit the TRPM7 channel. The manuscript has been published in the Journal of Natural Products.

In this study, Drs. Suzuki and Fleig collaborated with a multi-disciplinary of chemists and physiologists to characterize the structure-activity relationships of waixenicin A, a xenicane diterpene from the Hawaiian coral Sarcothelia edmondsoni. Waixenicin A is a selective and potent inhibitor of the TRPM7 ion channel, which is

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