Dr. Faouzi’s study reports for the first time that several minor cannabinoids, mainly the carboxylic acid derivatives and particularly cannabigerolic acid (CBGA), demonstrated high potency against Store-Operated Calcium Entry (SOCE) by blocking Calcium Release-Activated Calcium (CRAC) currents. SOCE, is the most significant calcium influx mechanism in immune cells and is critical for T cell activation. This study shows that inhibition of SOCE by CBGA resulted in a decrease of Nuclear Factor of Activated T-cells (NFAT) activation and Interleukin 2 (IL-2) production in human T lymphocytes.