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Dr. Malika Faouzi and colleagues show that minor cannabinoids may be responsible for the anti-inflammatory and analgesic effects of Cannabis. This study has been published in the journal Function.

Dr. Faouzi’s study reports for the first time that several minor cannabinoids, mainly the carboxylic acid derivatives and particularly cannabigerolic acid (CBGA), demonstrated high potency against Store-Operated Calcium Entry (SOCE) by blocking Calcium Release-Activated Calcium (CRAC) currents. SOCE, is the most significant calcium influx mechanism in immune cells and is critical for T cell activation. This study shows that inhibition of SOCE by CBGA resulted in a decrease of Nuclear Factor of Activated T-cells (NFAT) activation and Interleukin 2 (IL-2) production in human T lymphocytes.