Drs. Sayuri Suzuki, Andrea Fleig, and colleagues identify the bioactive sites on waixenicin A that inhibit the TRPM7 channel. The manuscript has been published in the Journal of Natural Products.
April 1, 2024
In this study, Drs. Suzuki and Fleig collaborated with a multi-disciplinary of chemists and physiologists to characterize the structure-activity relationships of waixenicin A, a xenicane diterpene from the Hawaiian coral Sarcothelia edmondsoni. Waixenicin A is a selective and potent inhibitor of the TRPM7 ion channel, which is
