QCBR Publications
Pharmacology of JNJ-28583113: A novel TRPM2 antagonist
Fourgeaud, L., Dvorak, C., Faouzi, M., Starkus, J., Sahdeo, S., Wang, Q., Lord, B., Coate, H., Taylor, N., He, Y., Qin, N., Wickenden, A., Carruthers, N., Lovenberg, T. W., Penner, R., & Bhattacharya, A.
European Journal of Pharmacology 853, 299–307 (2019).
DOI: https://doi.org/10.1016/j.ejphar.2019.03.043. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30965058
Fourgeaud, L., Dvorak, C., Faouzi, M., Starkus, J., Sahdeo, S., Wang, Q., Lord, B., Coate, H., Taylor, N., He, Y., Qin, N., Wickenden, A., Carruthers, N., Lovenberg, T. W., Penner, R., & Bhattacharya, A.
European Journal of Pharmacology 853, 299–307 (2019).
DOI: https://doi.org/10.1016/j.ejphar.2019.03.043. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30965058
Areca nut extracts mobilize calcium and release pro-inflammatory cytokines from various immune cells
Faouzi, M., Neupane, R. P., Yang, J., Williams, P., & Penner, R.
Scientific Reports 8(1), 1075 (2018).
DOI: https://doi.org/10.1038/s41598-017-18996-2. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773534
Faouzi, M., Neupane, R. P., Yang, J., Williams, P., & Penner, R.
Scientific Reports 8(1), 1075 (2018).
DOI: https://doi.org/10.1038/s41598-017-18996-2. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773534
TRPM7 channels play a role in high glucose-induced endoplasmic reticulum stress and neuronal cell apoptosis
Huang, Y., Leng, T.-D., Inoue, K., Yang, T., Liu, M., Horgen, F. D., Fleig, A., Li, J., & Xiong, Z.-G.
The Journal of Biological Chemistry 293(37), 14393–14406 (2018).
DOI: https://doi.org/10.1074/jbc.RA117.001032. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139551
Huang, Y., Leng, T.-D., Inoue, K., Yang, T., Liu, M., Horgen, F. D., Fleig, A., Li, J., & Xiong, Z.-G.
The Journal of Biological Chemistry 293(37), 14393–14406 (2018).
DOI: https://doi.org/10.1074/jbc.RA117.001032. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139551
The TRPM7 kinase limits receptor-induced calcium release by regulating heterotrimeric G-proteins
Suzuki, S., Lis, A., Schmitz, C., Penner, R., & Fleig, A.
Cellular and Molecular Life Sciences: CMLS 75(16), 3069–3078 (2018).
DOI: https://doi.org/10.1007/s00018-018-2786-z. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033657
Suzuki, S., Lis, A., Schmitz, C., Penner, R., & Fleig, A.
Cellular and Molecular Life Sciences: CMLS 75(16), 3069–3078 (2018).
DOI: https://doi.org/10.1007/s00018-018-2786-z. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033657
The TRPM7 channel kinase regulates store-operated calcium entry
Faouzi, M., Kilch, T., Horgen, F. D., Fleig, A., & Penner, R.
The Journal of Physiology 595(10), 3165–3180 (2017).
DOI: https://doi.org/10.1113/JP274006. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430208
Faouzi, M., Kilch, T., Horgen, F. D., Fleig, A., & Penner, R.
The Journal of Physiology 595(10), 3165–3180 (2017).
DOI: https://doi.org/10.1113/JP274006. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430208
New insights into Ca2+ channel function in health and disease
Fleig, A., & Parekh, A. B.
The Journal of Physiology 595(10), 2997–2998 (2017).
DOI: https://doi.org/10.1113/JP274289. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430230
Fleig, A., & Parekh, A. B.
The Journal of Physiology 595(10), 2997–2998 (2017).
DOI: https://doi.org/10.1113/JP274289. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430230
Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice
Huang, J., Furuya, H., Faouzi, M., Zhang, Z., Monteilh-Zoller, M., Kawabata, K. G., Horgen, F. D., Kawamori, T., Penner, R., & Fleig, A.
Cell Communication and Signaling: CCS 15(1), 30 (2017).
DOI: https://doi.org/10.1186/s12964-017-0187-9. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558780
Huang, J., Furuya, H., Faouzi, M., Zhang, Z., Monteilh-Zoller, M., Kawabata, K. G., Horgen, F. D., Kawamori, T., Penner, R., & Fleig, A.
Cell Communication and Signaling: CCS 15(1), 30 (2017).
DOI: https://doi.org/10.1186/s12964-017-0187-9. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558780
Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion
Sisquella, X., Nebl, T., Thompson, J. K., Whitehead, L., Malpede, B. M., Salinas, N. D., Rogers, K., Tolia, N. H., Fleig, A., O’Neill, J., Tham, W.-H., David Horgen, F., & Cowman, A. F.
ELife 6 (2017).
DOI: https://doi.org/10.7554/eLife.21083. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333951
Sisquella, X., Nebl, T., Thompson, J. K., Whitehead, L., Malpede, B. M., Salinas, N. D., Rogers, K., Tolia, N. H., Fleig, A., O’Neill, J., Tham, W.-H., David Horgen, F., & Cowman, A. F.
ELife 6 (2017).
DOI: https://doi.org/10.7554/eLife.21083. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333951
Scalaradial Is a potent inhibitor of Transient Receptor Potential Melastatin 2 (TRPM2) ion channels
Starkus, J. G., Poerzgen, P., Layugan, K., Kawabata, K. G., Goto, J.-I., Suzuki, S., Myers, G., Kelly, M., Penner, R., Fleig, A., & Horgen, F. D.
Journal of Natural Products 80(10), 2741–2750 (2017).
DOI: https://doi.org/10.1021/acs.jnatprod.7b00515. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29019677
Starkus, J. G., Poerzgen, P., Layugan, K., Kawabata, K. G., Goto, J.-I., Suzuki, S., Myers, G., Kelly, M., Penner, R., Fleig, A., & Horgen, F. D.
Journal of Natural Products 80(10), 2741–2750 (2017).
DOI: https://doi.org/10.1021/acs.jnatprod.7b00515. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29019677
The coiled-coil domain of zebrafish TRPM7 regulates Mg·nucleotide sensitivity
Jansen, C., Sahni, J., Suzuki, S., Horgen, F. D., Penner, R., & Fleig, A.
Scientific Reports 6, 33459 (2016).
DOI: https://doi.org/10.1038/srep33459. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024298
Jansen, C., Sahni, J., Suzuki, S., Horgen, F. D., Penner, R., & Fleig, A.
Scientific Reports 6, 33459 (2016).
DOI: https://doi.org/10.1038/srep33459. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024298
Human CNNM2 is not a Mg2+ transporter per se
Sponder, G., Mastrototaro, L., Kurth, K., Merolle, L., Zhang, Z., Abdulhanan, N., Smorodchenko, A., Wolf, K., Fleig, A., Penner, R., Iotti, S., Aschenbach, J. R., Vormann, J., & Kolisek, M.
Pflugers Archiv: European Journal of Physiology 468(7), 1223–1240 (2016).
DOI: https://doi.org/10.1007/s00424-016-1816-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/27068403
Sponder, G., Mastrototaro, L., Kurth, K., Merolle, L., Zhang, Z., Abdulhanan, N., Smorodchenko, A., Wolf, K., Fleig, A., Penner, R., Iotti, S., Aschenbach, J. R., Vormann, J., & Kolisek, M.
Pflugers Archiv: European Journal of Physiology 468(7), 1223–1240 (2016).
DOI: https://doi.org/10.1007/s00424-016-1816-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/27068403
TRPM7 regulates axonal outgrowth and maturation of primary hippocampal neurons
Turlova, E., Bae, C. Y. J., Deurloo, M., Chen, W., Barszczyk, A., Horgen, F. D., Fleig, A., Feng, Z.-P., & Sun, H.-S.
Molecular Neurobiology 53(1), 595–610 (2016).
DOI: https://doi.org/10.1007/s12035-014-9032-y. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820394
Turlova, E., Bae, C. Y. J., Deurloo, M., Chen, W., Barszczyk, A., Horgen, F. D., Fleig, A., Feng, Z.-P., & Sun, H.-S.
Molecular Neurobiology 53(1), 595–610 (2016).
DOI: https://doi.org/10.1007/s12035-014-9032-y. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820394
TRPM7 kinase activity regulates murine mast cell degranulation
Zierler, S., Sumoza-Toledo, A., Suzuki, S., Dúill, F. Ó., Ryazanova, L. V., Penner, R., Ryazanov, A. G., & Fleig, A.
The Journal of Physiology 594(11), 2957–2970 (2016).
DOI: https://doi.org/10.1113/JP271564. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887679
Zierler, S., Sumoza-Toledo, A., Suzuki, S., Dúill, F. Ó., Ryazanova, L. V., Penner, R., Ryazanov, A. G., & Fleig, A.
The Journal of Physiology 594(11), 2957–2970 (2016).
DOI: https://doi.org/10.1113/JP271564. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887679
State-dependent blocking mechanism of Kv1.3 channels by the antimycobacterial drug clofazimine
Faouzi, M., Starkus, J., & Penner, R.
British Journal of Pharmacology 172(21), 5161–5173 (2015).
DOI: https://doi.org/10.1111/bph.13283. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687807
Faouzi, M., Starkus, J., & Penner, R.
British Journal of Pharmacology 172(21), 5161–5173 (2015).
DOI: https://doi.org/10.1111/bph.13283. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687807
Small-conductance Ca2+-activated potassium type 2 channels regulate the formation of contextual fear memory
Murthy, S. R. K., Sherrin, T., Jansen, C., Nijholt, I., Robles, M., Dolga, A. M., Andreotti, N., Sabatier, J.-M., Knaus, H.-G., Penner, R., Todorovic, C., & Blank, T.
PloS One 10(5), e0127264 (2015).
DOI: https://doi.org/10.1371/journal.pone.0127264. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418695
Murthy, S. R. K., Sherrin, T., Jansen, C., Nijholt, I., Robles, M., Dolga, A. M., Andreotti, N., Sabatier, J.-M., Knaus, H.-G., Penner, R., Todorovic, C., & Blank, T.
PloS One 10(5), e0127264 (2015).
DOI: https://doi.org/10.1371/journal.pone.0127264. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418695
Regulation of endogenous and heterologous Ca2+ release-activated Ca2+ currents by pH
Beck, A., Fleig, A., Penner, R., & Peinelt, C.
Cell Calcium 56(3), 235–243 (2014).
DOI: https://doi.org/10.1016/j.ceca.2014.07.011. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162834
Beck, A., Fleig, A., Penner, R., & Peinelt, C.
Cell Calcium 56(3), 235–243 (2014).
DOI: https://doi.org/10.1016/j.ceca.2014.07.011. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162834
TRPM2
Faouzi, M., & Penner, R.
Handbook of Experimental Pharmacology 222, 403–426 (2014).
DOI: https://doi.org/10.1007/978-3-642-54215-2_16. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24756715
Faouzi, M., & Penner, R.
Handbook of Experimental Pharmacology 222, 403–426 (2014).
DOI: https://doi.org/10.1007/978-3-642-54215-2_16. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24756715
TRPM7
Fleig, A., & Chubanov, V.
Handbook of Experimental Pharmacology 222, 521–546 (2014).
DOI: https://doi.org/10.1007/978-3-642-54215-2_21. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663634
Fleig, A., & Chubanov, V.
Handbook of Experimental Pharmacology 222, 521–546 (2014).
DOI: https://doi.org/10.1007/978-3-642-54215-2_21. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663634
Elucidating the role of the TRPM7 alpha-kinase: TRPM7 kinase inactivation leads to magnesium deprivation resistance phenotype in mice
Ryazanova, L. V., Hu, Z., Suzuki, S., Chubanov, V., Fleig, A., & Ryazanov, A. G.
Scientific Reports 4, 7599 (2014).
DOI: https://doi.org/10.1038/srep07599. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274504
Ryazanova, L. V., Hu, Z., Suzuki, S., Chubanov, V., Fleig, A., & Ryazanov, A. G.
Scientific Reports 4, 7599 (2014).
DOI: https://doi.org/10.1038/srep07599. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274504
N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation
Zhang, Z., Faouzi, M., Huang, J., Geerts, D., Yu, H., Fleig, A., & Penner, R.
Oncotarget 5(17), 7625–7634 (2014).
DOI: https://doi.org/10.18632/oncotarget.2283. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202149
Zhang, Z., Faouzi, M., Huang, J., Geerts, D., Yu, H., Fleig, A., & Penner, R.
Oncotarget 5(17), 7625–7634 (2014).
DOI: https://doi.org/10.18632/oncotarget.2283. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202149
The TRPM6 kinase domain determines the Mg·ATP sensitivity of TRPM7/M6 heteromeric ion channels
Zhang, Z., Yu, H., Huang, J., Faouzi, M., Schmitz, C., Penner, R., & Fleig, A.
The Journal of Biological Chemistry 289(8), 5217–5227 (2014).
DOI: https://doi.org/10.1074/jbc.M113.512285. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931078
Zhang, Z., Yu, H., Huang, J., Faouzi, M., Schmitz, C., Penner, R., & Fleig, A.
The Journal of Biological Chemistry 289(8), 5217–5227 (2014).
DOI: https://doi.org/10.1074/jbc.M113.512285. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931078
ORAI3 silencing alters cell proliferation and cell cycle progression via c-myc pathway in breast cancer cells
Faouzi, M., Kischel, P., Hague, F., Ahidouch, A., Benzerdjeb, N., Sevestre, H., Penner, R., & Ouadid-Ahidouch, H.
Biochimica et Biophysica Acta 1833(3), 752–760 (2013).
DOI: https://doi.org/10.1016/j.bbamcr.2012.12.009. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23266555
Faouzi, M., Kischel, P., Hague, F., Ahidouch, A., Benzerdjeb, N., Sevestre, H., Penner, R., & Ouadid-Ahidouch, H.
Biochimica et Biophysica Acta 1833(3), 752–760 (2013).
DOI: https://doi.org/10.1016/j.bbamcr.2012.12.009. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23266555
Solute Carrier Family SLC41, what do we really know about it?
Fleig, A., Schweigel-Röntgen, M., & Kolisek, M.
Wiley Interdisciplinary Reviews. Membrane Transport and Signaling 2(6) (2013).
DOI: https://doi.org/10.1002/wmts.95. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855994
Fleig, A., Schweigel-Röntgen, M., & Kolisek, M.
Wiley Interdisciplinary Reviews. Membrane Transport and Signaling 2(6) (2013).
DOI: https://doi.org/10.1002/wmts.95. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855994
TRPM2 channels are not required for acute airway inflammation in OVA-induced severe allergic asthma in mice
Sumoza-Toledo, A., Fleig, A., & Penner, R.
Journal of Inflammation (London, England) 10(1), 19 (2013).
DOI: https://doi.org/10.1186/1476-9255-10-19. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23631390
Sumoza-Toledo, A., Fleig, A., & Penner, R.
Journal of Inflammation (London, England) 10(1), 19 (2013).
DOI: https://doi.org/10.1186/1476-9255-10-19. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23631390
STIM2 drives Ca2+ oscillations through store-operated Ca2+ entry caused by mild store depletion
Thiel, M., Lis, A., & Penner, R.
The Journal of Physiology 591(Pt 6), 1433–1445 (2013).
DOI: https://doi.org/10.1113/jphysiol.2012.245399. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23359669
Thiel, M., Lis, A., & Penner, R.
The Journal of Physiology 591(Pt 6), 1433–1445 (2013).
DOI: https://doi.org/10.1113/jphysiol.2012.245399. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23359669
TRPM7 triggers Ca2+ sparks and invadosome formation in neuroblastoma cells
Visser, D., Langeslag, M., Kedziora, K. M., Klarenbeek, J., Kamermans, A., Horgen, F. D., Fleig, A., van Leeuwen, F. N., & Jalink, K.
Cell Calcium 54(6), 404–415 (2013).
DOI: https://doi.org/10.1016/j.ceca.2013.09.003. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912378
Visser, D., Langeslag, M., Kedziora, K. M., Klarenbeek, J., Kamermans, A., Horgen, F. D., Fleig, A., van Leeuwen, F. N., & Jalink, K.
Cell Calcium 54(6), 404–415 (2013).
DOI: https://doi.org/10.1016/j.ceca.2013.09.003. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912378
TRPM7 is regulated by halides through its kinase domain
Yu, H., Zhang, Z., Lis, A., Penner, R., & Fleig, A.
Cellular and Molecular Life Sciences: CMLS (2013).
DOI: https://doi.org/10.1007/s00018-013-1284-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23471296
Yu, H., Zhang, Z., Lis, A., Penner, R., & Fleig, A.
Cellular and Molecular Life Sciences: CMLS (2013).
DOI: https://doi.org/10.1007/s00018-013-1284-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23471296
Stimulation of Ca2+ channel Orai1/STIM1 by serum- and glucocorticoid-inducible kinase 1 (SGK1)
Eylenstein, A., Gehring, E.-M., Heise, N., Shumilina, E., Schmidt, S., Szteyn, K., Münzer, P., Nurbaeva, M. K., Eichenmüller, M., Tyan, L., Regel, I., Föller, M., Kuhl, D., Soboloff, J., Penner, R., & Lang, F.
The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 25(6), 2012–2021 (2011).
DOI: https://doi.org/10.1096/fj.10-178210. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21385992
Eylenstein, A., Gehring, E.-M., Heise, N., Shumilina, E., Schmidt, S., Szteyn, K., Münzer, P., Nurbaeva, M. K., Eichenmüller, M., Tyan, L., Regel, I., Föller, M., Kuhl, D., Soboloff, J., Penner, R., & Lang, F.
The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 25(6), 2012–2021 (2011).
DOI: https://doi.org/10.1096/fj.10-178210. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21385992
Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release
Sumoza-Toledo, A., Lange, I., Cortado, H., Bhagat, H., Mori, Y., Fleig, A., Penner, R., & Partida-Sánchez, S.
The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 25(10), 3529–3542 (2011).
DOI: https://doi.org/10.1096/fj.10-178483. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21753080
Sumoza-Toledo, A., Lange, I., Cortado, H., Bhagat, H., Mori, Y., Fleig, A., Penner, R., & Partida-Sánchez, S.
The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 25(10), 3529–3542 (2011).
DOI: https://doi.org/10.1096/fj.10-178483. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21753080
TRPM2: A multifunctional ion channel for calcium signaling
Sumoza-Toledo, A., & Penner, R.
The Journal of Physiology 589(Pt 7), 1515–1525 (2011).
DOI: https://doi.org/10.1113/jphysiol.2010.201855. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21135052
Sumoza-Toledo, A., & Penner, R.
The Journal of Physiology 589(Pt 7), 1515–1525 (2011).
DOI: https://doi.org/10.1113/jphysiol.2010.201855. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21135052
Waixenicin A inhibits cell proliferation through magnesium-dependent block of Transient Receptor Potential Melastatin 7 (TRPM7) channels
Zierler, S., Yao, G., Zhang, Z., Kuo, W. C., Pörzgen, P., Penner, R., Horgen, F. D., & Fleig, A.
The Journal of Biological Chemistry 286(45), 39328–39335 (2011).
DOI: https://doi.org/10.1074/jbc.M111.264341. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21926172
Zierler, S., Yao, G., Zhang, Z., Kuo, W. C., Pörzgen, P., Penner, R., Horgen, F. D., & Fleig, A.
The Journal of Biological Chemistry 286(45), 39328–39335 (2011).
DOI: https://doi.org/10.1074/jbc.M111.264341. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21926172
TRPM5 regulates glucose-stimulated insulin secretion
Brixel, L. R., Monteilh-Zoller, M. K., Ingenbrandt, C. S., Fleig, A., Penner, R., Enklaar, T., Zabel, B. U., & Prawitt, D.
Pflügers Archiv: European Journal of Physiology 460(1), 69–76 (2010).
DOI: https://doi.org/10.1007/s00424-010-0835-z. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20393858
Brixel, L. R., Monteilh-Zoller, M. K., Ingenbrandt, C. S., Fleig, A., Penner, R., Enklaar, T., Zabel, B. U., & Prawitt, D.
Pflügers Archiv: European Journal of Physiology 460(1), 69–76 (2010).
DOI: https://doi.org/10.1007/s00424-010-0835-z. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20393858
Development and optimization of a high-throughput bioassay for TRPM7 ion channel inhibitors
Castillo, B., Pörzgen, P., Penner, R., Horgen, F. D., & Fleig, A.
Journal of Biomolecular Screening 15(5), 498–507 (2010).
DOI: https://doi.org/10.1177/1087057110368294. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20413646
Castillo, B., Pörzgen, P., Penner, R., Horgen, F. D., & Fleig, A.
Journal of Biomolecular Screening 15(5), 498–507 (2010).
DOI: https://doi.org/10.1177/1087057110368294. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20413646
Two novel 2-aminoethyl diphenylborinate (2-APB) analogues differentially activate and inhibit store-operated Ca2+ entry via STIM proteins
Goto, J.-I., Suzuki, A. Z., Ozaki, S., Matsumoto, N., Nakamura, T., Ebisui, E., Fleig, A., Penner, R., & Mikoshiba, K.
Cell Calcium 47(1), 1–10 (2010).
DOI: https://doi.org/10.1016/j.ceca.2009.10.004. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19945161
Goto, J.-I., Suzuki, A. Z., Ozaki, S., Matsumoto, N., Nakamura, T., Ebisui, E., Fleig, A., Penner, R., & Mikoshiba, K.
Cell Calcium 47(1), 1–10 (2010).
DOI: https://doi.org/10.1016/j.ceca.2009.10.004. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19945161
Activation of store-operated ICRAC by hydrogen peroxide
Grupe, M., Myers, G., Penner, R., & Fleig, A.
Cell Calcium 48(1), 1–9 (2010).
DOI: https://doi.org/10.1016/j.ceca.2010.05.005. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20646759
Grupe, M., Myers, G., Penner, R., & Fleig, A.
Cell Calcium 48(1), 1–9 (2010).
DOI: https://doi.org/10.1016/j.ceca.2010.05.005. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20646759
A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating
Lis, A., Zierler, S., Peinelt, C., Fleig, A., & Penner, R.
The Journal of General Physiology 136(6), 673–686 (2010).
DOI: https://doi.org/10.1085/jgp.201010484. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21115697
Lis, A., Zierler, S., Peinelt, C., Fleig, A., & Penner, R.
The Journal of General Physiology 136(6), 673–686 (2010).
DOI: https://doi.org/10.1085/jgp.201010484. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21115697
TRPM7 is essential for Mg2+ homeostasis in mammals
Ryazanova, L. V., Rondon, L. J., Zierler, S., Hu, Z., Galli, J., Yamaguchi, T. P., Mazur, A., Fleig, A., & Ryazanov, A. G.
Nature Communications 1, 109 (2010).
DOI: https://doi.org/10.1038/ncomms1108. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060619
Ryazanova, L. V., Rondon, L. J., Zierler, S., Hu, Z., Galli, J., Yamaguchi, T. P., Mazur, A., Fleig, A., & Ryazanov, A. G.
Nature Communications 1, 109 (2010).
DOI: https://doi.org/10.1038/ncomms1108. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060619
The calcium-permeable non-selective cation channel TRPM2 is modulated by cellular acidification
Starkus, J. G., Fleig, A., & Penner, R.
The Journal of Physiology 588(Pt 8), 1227–1240 (2010).
DOI: https://doi.org/10.1113/jphysiol.2010.187476. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20194125
Starkus, J. G., Fleig, A., & Penner, R.
The Journal of Physiology 588(Pt 8), 1227–1240 (2010).
DOI: https://doi.org/10.1113/jphysiol.2010.187476. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20194125
TRPM2 functions as a lysosomal Ca2+-release channel in beta cells
Lange, I., Yamamoto, S., Partida-Sanchez, S., Mori, Y., Fleig, A., & Penner, R.
Science Signaling 2(71), ra23 (2009).
DOI: https://doi.org/10.1126/scisignal.2000278. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19454650
Lange, I., Yamamoto, S., Partida-Sanchez, S., Mori, Y., Fleig, A., & Penner, R.
Science Signaling 2(71), ra23 (2009).
DOI: https://doi.org/10.1126/scisignal.2000278. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19454650
IP3 receptor subtype-dependent activation of store-operated calcium entry through ICRAC
Peinelt, C., Beck, A., Monteilh-Zoller, M. K., Penner, R., & Fleig, A.
Cell Calcium 45(4), 326–330 (2009).
DOI: https://doi.org/10.1016/j.ceca.2008.12.001. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19157540
Peinelt, C., Beck, A., Monteilh-Zoller, M. K., Penner, R., & Fleig, A.
Cell Calcium 45(4), 326–330 (2009).
DOI: https://doi.org/10.1016/j.ceca.2008.12.001. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19157540
Lipopolysaccharide-induced down-regulation of Ca2+ release-activated Ca2+ currents (ICRAC) but not Ca2+-activated TRPM4-like currents (ICAN) in cultured mouse microglial cells
Beck, A., Penner, R., & Fleig, A.
The Journal of Physiology 586(2), 427–439 (2008).
DOI: https://doi.org/10.1113/jphysiol.2007.145151. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17991695
Beck, A., Penner, R., & Fleig, A.
The Journal of Physiology 586(2), 427–439 (2008).
DOI: https://doi.org/10.1113/jphysiol.2007.145151. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17991695
SLC41A1 is a novel mammalian Mg2+ carrier
Kolisek, M., Launay, P., Beck, A., Sponder, G., Serafini, N., Brenkus, M., Froschauer, E. M., Martens, H., Fleig, A., & Schweigel, M.
The Journal of Biological Chemistry 283(23), 16235–16247 (2008).
DOI: https://doi.org/10.1074/jbc.M707276200. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2414286
Kolisek, M., Launay, P., Beck, A., Sponder, G., Serafini, N., Brenkus, M., Froschauer, E. M., Martens, H., Fleig, A., & Schweigel, M.
The Journal of Biological Chemistry 283(23), 16235–16247 (2008).
DOI: https://doi.org/10.1074/jbc.M707276200. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2414286
Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils
Lange, I., Penner, R., Fleig, A., & Beck, A.
Cell Calcium 44(6), 604–615 (2008).
DOI: https://doi.org/10.1016/j.ceca.2008.05.001. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18572241
Lange, I., Penner, R., Fleig, A., & Beck, A.
Cell Calcium 44(6), 604–615 (2008).
DOI: https://doi.org/10.1016/j.ceca.2008.05.001. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18572241
STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation
Parvez, S., Beck, A., Peinelt, C., Soboloff, J., Lis, A., Monteilh-Zoller, M., Gill, D. L., Fleig, A., & Penner, R.
The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 22(3), 752–761 (2008).
DOI: https://doi.org/10.1096/fj.07-9449com. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17905723
Parvez, S., Beck, A., Peinelt, C., Soboloff, J., Lis, A., Monteilh-Zoller, M., Gill, D. L., Fleig, A., & Penner, R.
The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 22(3), 752–761 (2008).
DOI: https://doi.org/10.1096/fj.07-9449com. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17905723
2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels
Peinelt, C., Lis, A., Beck, A., Fleig, A., & Penner, R.
The Journal of Physiology 586(13), 3061–3073 (2008).
DOI: https://doi.org/10.1113/jphysiol.2008.151365. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18403424
Peinelt, C., Lis, A., Beck, A., Fleig, A., & Penner, R.
The Journal of Physiology 586(13), 3061–3073 (2008).
DOI: https://doi.org/10.1113/jphysiol.2008.151365. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18403424
Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes
Ren, Y. R., Pan, F., Parvez, S., Fleig, A., Chong, C. R., Xu, J., Dang, Y., Zhang, J., Jiang, H., Penner, R., & Liu, J. O.
PloS One 3(12), e4009 (2008).
DOI: https://doi.org/10.1371/journal.pone.0004009. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19104661
Ren, Y. R., Pan, F., Parvez, S., Fleig, A., Chong, C. R., Xu, J., Dang, Y., Zhang, J., Jiang, H., Penner, R., & Liu, J. O.
PloS One 3(12), e4009 (2008).
DOI: https://doi.org/10.1371/journal.pone.0004009. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19104661
TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration
Yamamoto, S., Shimizu, S., Kiyonaka, S., Takahashi, N., Wajima, T., Hara, Y., Negoro, T., Hiroi, T., Kiuchi, Y., Okada, T., Kaneko, S., Lange, I., Fleig, A., Penner, R., Nishi, M., Takeshima, H., & Mori, Y.
Nature Medicine 14(7), 738–747 (2008).
DOI: https://doi.org/10.1038/nm1758. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18542050
Yamamoto, S., Shimizu, S., Kiyonaka, S., Takahashi, N., Wajima, T., Hara, Y., Negoro, T., Hiroi, T., Kiuchi, Y., Okada, T., Kaneko, S., Lange, I., Fleig, A., Penner, R., Nishi, M., Takeshima, H., & Mori, Y.
Nature Medicine 14(7), 738–747 (2008).
DOI: https://doi.org/10.1038/nm1758. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18542050
TRPM7 channel is sensitive to osmotic gradients in human kidney cells
Bessac, B. F., & Fleig, A.
The Journal of Physiology 582(Pt 3), 1073–1086 (2007).
DOI: https://doi.org/10.1113/jphysiol.2007.130534. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075261
Bessac, B. F., & Fleig, A.
The Journal of Physiology 582(Pt 3), 1073–1086 (2007).
DOI: https://doi.org/10.1113/jphysiol.2007.130534. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075261
TRPM4 controls insulin secretion in pancreatic β-cells
Cheng, H., Beck, A., Launay, P., Gross, S. A., Stokes, A. J., Kinet, J.-P., Fleig, A., & Penner, R.
Cell Calcium 41(1), 51–61 (2007).
DOI: https://doi.org/10.1016/j.ceca.2006.04.032. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16806463
Cheng, H., Beck, A., Launay, P., Gross, S. A., Stokes, A. J., Kinet, J.-P., Fleig, A., & Penner, R.
Cell Calcium 41(1), 51–61 (2007).
DOI: https://doi.org/10.1016/j.ceca.2006.04.032. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16806463
CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties
Lis, A., Peinelt, C., Beck, A., Parvez, S., Monteilh-Zoller, M., Fleig, A., & Penner, R.
Current Biology: CB 17(9), 794–800 (2007).
DOI: https://doi.org/10.1016/j.cub.2007.03.065. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17442569
Lis, A., Peinelt, C., Beck, A., Parvez, S., Monteilh-Zoller, M., Fleig, A., & Penner, R.
Current Biology: CB 17(9), 794–800 (2007).
DOI: https://doi.org/10.1016/j.cub.2007.03.065. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17442569
The Mg2+ and Mg2+-nucleotide-regulated channel-kinase TRPM7
Penner, R., & Fleig, A.
Handbook of Experimental Pharmacology 179(179), 313–328 (2007).
DOI: https://doi.org/10.1007/978-3-540-34891-7_19. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17217066
Penner, R., & Fleig, A.
Handbook of Experimental Pharmacology 179(179), 313–328 (2007).
DOI: https://doi.org/10.1007/978-3-540-34891-7_19. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17217066
Regulation of TRPM2 by extra- and intracellular calcium
Starkus, J., Beck, A., Fleig, A., & Penner, R.
The Journal of General Physiology 130(4), 427–440 (2007).
DOI: https://doi.org/10.1085/jgp.200709836. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17893195
Starkus, J., Beck, A., Fleig, A., & Penner, R.
The Journal of General Physiology 130(4), 427–440 (2007).
DOI: https://doi.org/10.1085/jgp.200709836. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17893195
Cell cycle-dependent regulation of store-operated ICRAC and Mg2+-nucleotide-regulated MagNuM (TRPM7) currents
Tani, D., Monteilh-Zoller, M. K., Fleig, A., & Penner, R.
Cell Calcium 41(3), 249–260 (2007).
DOI: https://doi.org/10.1016/j.ceca.2006.07.004. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17064762
Tani, D., Monteilh-Zoller, M. K., Fleig, A., & Penner, R.
Cell Calcium 41(3), 249–260 (2007).
DOI: https://doi.org/10.1016/j.ceca.2006.07.004. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17064762
Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes
Beck, A., Kolisek, M., Bagley, L. A., Fleig, A., & Penner, R.
The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 20(7), 962–964 (2006).
DOI: https://doi.org/10.1096/fj.05-5538fje. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16585058
Beck, A., Kolisek, M., Bagley, L. A., Fleig, A., & Penner, R.
The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 20(7), 962–964 (2006).
DOI: https://doi.org/10.1096/fj.05-5538fje. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16585058
TRPM7 channel is regulated by magnesium nucleotides via its kinase domain
Demeuse, P., Penner, R., & Fleig, A.
The Journal of General Physiology 127(4), 421–434 (2006).
DOI: https://doi.org/10.1085/jgp.200509410. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16533898
Demeuse, P., Penner, R., & Fleig, A.
The Journal of General Physiology 127(4), 421–434 (2006).
DOI: https://doi.org/10.1085/jgp.200509410. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16533898
Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
Peinelt, C., Vig, M., Koomoa, D. L., Beck, A., Nadler, M. J. S., Koblan-Huberson, M., Lis, A., Fleig, A., Penner, R., & Kinet, J.-P.
Nature Cell Biology 8(7), 771–773 (2006).
DOI: https://doi.org/10.1038/ncb1435. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16733527
Peinelt, C., Vig, M., Koomoa, D. L., Beck, A., Nadler, M. J. S., Koblan-Huberson, M., Lis, A., Fleig, A., Penner, R., & Kinet, J.-P.
Nature Cell Biology 8(7), 771–773 (2006).
DOI: https://doi.org/10.1038/ncb1435. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16733527
TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD
Stokes, A., Wakano, C., Koblan-Huberson, M., Adra, C. N., Fleig, A., & Turner, H.
Cellular Signalling 18(10), 1584–1594 (2006).
DOI: https://doi.org/10.1016/j.cellsig.2005.12.009. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16500080
Stokes, A., Wakano, C., Koblan-Huberson, M., Adra, C. N., Fleig, A., & Turner, H.
Cellular Signalling 18(10), 1584–1594 (2006).
DOI: https://doi.org/10.1016/j.cellsig.2005.12.009. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16500080
A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity
Takezawa, R., Cheng, H., Beck, A., Ishikawa, J., Launay, P., Kubota, H., Kinet, J.-P., Fleig, A., Yamada, T., & Penner, R.
Molecular Pharmacology 69(4), 1413–1420 (2006).
DOI: https://doi.org/10.1124/mol.105.021154. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16407466
Takezawa, R., Cheng, H., Beck, A., Ishikawa, J., Launay, P., Kubota, H., Kinet, J.-P., Fleig, A., Yamada, T., & Penner, R.
Molecular Pharmacology 69(4), 1413–1420 (2006).
DOI: https://doi.org/10.1124/mol.105.021154. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16407466
CRACM1 multimers form the ion-selective pore of the CRAC channel
Vig, M., Beck, A., Billingsley, J. M., Lis, A., Parvez, S., Peinelt, C., Koomoa, D. L., Soboloff, J., Gill, D. L., Fleig, A., Kinet, J.-P., & Penner, R.
Current Biology: CB 16(20), 2073–2079 (2006).
DOI: https://doi.org/10.1016/j.cub.2006.08.085. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16978865
Vig, M., Beck, A., Billingsley, J. M., Lis, A., Parvez, S., Peinelt, C., Koomoa, D. L., Soboloff, J., Gill, D. L., Fleig, A., Kinet, J.-P., & Penner, R.
Current Biology: CB 16(20), 2073–2079 (2006).
DOI: https://doi.org/10.1016/j.cub.2006.08.085. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16978865
CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry
Vig, M., Peinelt, C., Beck, A., Koomoa, D. L., Rabah, D., Koblan-Huberson, M., Kraft, S., Turner, H., Fleig, A., Penner, R., & Kinet, J.-P.
Science (New York, N.Y.) 312(5777), 1220–1223 (2006).
DOI: https://doi.org/10.1126/science.1127883. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16645049
Vig, M., Peinelt, C., Beck, A., Koomoa, D. L., Rabah, D., Koblan-Huberson, M., Kraft, S., Turner, H., Fleig, A., Penner, R., & Kinet, J.-P.
Science (New York, N.Y.) 312(5777), 1220–1223 (2006).
DOI: https://doi.org/10.1126/science.1127883. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16645049
Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels
Kolisek, M., Beck, A., Fleig, A., & Penner, R.
Molecular Cell 18(1), 61–69 (2005).
DOI: https://doi.org/10.1016/j.molcel.2005.02.033. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15808509
Kolisek, M., Beck, A., Fleig, A., & Penner, R.
Molecular Cell 18(1), 61–69 (2005).
DOI: https://doi.org/10.1016/j.molcel.2005.02.033. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15808509
Emerging roles of TRPM channels
Fleig, A., & Penner, R.
Novartis Foundation Symposium 258, 248–258; discussion 258-266 (2004).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/15104187
Fleig, A., & Penner, R.
Novartis Foundation Symposium 258, 248–258; discussion 258-266 (2004).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/15104187
The TRPM ion channel subfamily: Molecular, biophysical and functional features
Fleig, A., & Penner, R.
Trends in Pharmacological Sciences 25(12), 633–639 (2004).
DOI: https://doi.org/10.1016/j.tips.2004.10.004. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15530641
Fleig, A., & Penner, R.
Trends in Pharmacological Sciences 25(12), 633–639 (2004).
DOI: https://doi.org/10.1016/j.tips.2004.10.004. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15530641
D-6-Deoxy-myo-inositol 1,3,4,5-tetrakisphosphate, a mimic of d-myo-inositol 1,3,4,5-tetrakisphosphate: Biological activity and pH-dependent conformational properties
Horne, G., Maechling, C., Fleig, A., Hirata, M., Penner, R., Spiess, B., & Potter, B. V. L.
Biochemical and Biophysical Research Communications 320(4), 1262–1270 (2004).
DOI: https://doi.org/10.1016/j.bbrc.2004.06.079. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15249226
Horne, G., Maechling, C., Fleig, A., Hirata, M., Penner, R., Spiess, B., & Potter, B. V. L.
Biochemical and Biophysical Research Communications 320(4), 1262–1270 (2004).
DOI: https://doi.org/10.1016/j.bbrc.2004.06.079. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15249226
TRPM4 regulates calcium oscillations after T cell activation
Launay, P., Cheng, H., Srivatsan, S., Penner, R., Fleig, A., & Kinet, J.-P.
Science (New York, N.Y.) 306(5700), 1374–1377 (2004).
DOI: https://doi.org/10.1126/science.1098845. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15550671
Launay, P., Cheng, H., Srivatsan, S., Penner, R., Fleig, A., & Kinet, J.-P.
Science (New York, N.Y.) 306(5700), 1374–1377 (2004).
DOI: https://doi.org/10.1126/science.1098845. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15550671
Store-operated calcium entry: A tough nut to CRAC
Penner, R., & Fleig, A.
Science’s STKE: Signal Transduction Knowledge Environment 2004(243), pe38 (2004).
DOI: https://doi.org/10.1126/stke.2432004pe38. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15280580
Penner, R., & Fleig, A.
Science’s STKE: Signal Transduction Knowledge Environment 2004(243), pe38 (2004).
DOI: https://doi.org/10.1126/stke.2432004pe38. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15280580
Dual-function ion channel/protein kinases: Novel components of vertebrate magnesium regulatory mechanisms
Schmitz, C., Perraud, A.-L., Fleig, A., & Scharenberg, A. M.
Pediatric Research 55(5), 734–737 (2004).
DOI: https://doi.org/10.1203/01.PDR.0000117848.37520.A2. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14764909
Schmitz, C., Perraud, A.-L., Fleig, A., & Scharenberg, A. M.
Pediatric Research 55(5), 734–737 (2004).
DOI: https://doi.org/10.1203/01.PDR.0000117848.37520.A2. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14764909
Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain
Takezawa, R., Schmitz, C., Demeuse, P., Scharenberg, A. M., Penner, R., & Fleig, A.
Proceedings of the National Academy of Sciences of the United States of America 101(16), 6009–6014 (2004).
DOI: https://doi.org/10.1073/pnas.0307565101. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15069188
Takezawa, R., Schmitz, C., Demeuse, P., Scharenberg, A. M., Penner, R., & Fleig, A.
Proceedings of the National Academy of Sciences of the United States of America 101(16), 6009–6014 (2004).
DOI: https://doi.org/10.1073/pnas.0307565101. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15069188
TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions
Monteilh-Zoller, M. K., Hermosura, M. C., Nadler, M. J. S., Scharenberg, A. M., Penner, R., & Fleig, A.
The Journal of General Physiology 121(1), 49–60 (2003).
DOI: https://doi.org/10.1085/jgp.20028740. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217320
Monteilh-Zoller, M. K., Hermosura, M. C., Nadler, M. J. S., Scharenberg, A. M., Penner, R., & Fleig, A.
The Journal of General Physiology 121(1), 49–60 (2003).
DOI: https://doi.org/10.1085/jgp.20028740. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217320
TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i
Prawitt, D., Monteilh-Zoller, M. K., Brixel, L., Spangenberg, C., Zabel, B., Fleig, A., & Penner, R.
Proceedings of the National Academy of Sciences of the United States of America 100(25), 15166–15171 (2003).
DOI: https://doi.org/10.1073/pnas.2334624100. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14634208
Prawitt, D., Monteilh-Zoller, M. K., Brixel, L., Spangenberg, C., Zabel, B., Fleig, A., & Penner, R.
Proceedings of the National Academy of Sciences of the United States of America 100(25), 15166–15171 (2003).
DOI: https://doi.org/10.1073/pnas.2334624100. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14634208
Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7
Schmitz, C., Perraud, A.-L., Johnson, C. O., Inabe, K., Smith, M. K., Penner, R., Kurosaki, T., Fleig, A., & Scharenberg, A. M.
Cell 114(2), 191–200 (2003).
DOI: https://doi.org/10.1016/s0092-8674(03)00556-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12887921
Schmitz, C., Perraud, A.-L., Johnson, C. O., Inabe, K., Smith, M. K., Penner, R., Kurosaki, T., Fleig, A., & Scharenberg, A. M.
Cell 114(2), 191–200 (2003).
DOI: https://doi.org/10.1016/s0092-8674(03)00556-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12887921
Discrimination of intracellular calcium store subcompartments using TRPV1 (Transient Receptor Potential Channel, Vanilloid subfamily member 1) release channel activity
Turner, H., Fleig, A., Stokes, A., Kinet, J.-P., & Penner, R.
The Biochemical Journal 371(Pt 2), 341–350 (2003).
DOI: https://doi.org/10.1042/BJ20021381. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12513687
Turner, H., Fleig, A., Stokes, A., Kinet, J.-P., & Penner, R.
The Biochemical Journal 371(Pt 2), 341–350 (2003).
DOI: https://doi.org/10.1042/BJ20021381. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12513687
Dissociation of the store-operated calcium current ICRAC and the Mg-nucleotide-regulated metal ion current MagNuM
Hermosura, M. C., Monteilh-Zoller, M. K., Scharenberg, A. M., Penner, R., & Fleig, A.
The Journal of Physiology 539(Pt 2), 445–458 (2002).
DOI: https://doi.org/10.1113/jphysiol.2001.013361. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290162
Hermosura, M. C., Monteilh-Zoller, M. K., Scharenberg, A. M., Penner, R., & Fleig, A.
The Journal of Physiology 539(Pt 2), 445–458 (2002).
DOI: https://doi.org/10.1113/jphysiol.2001.013361. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290162
TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization
Launay, P., Fleig, A., Perraud, A. L., Scharenberg, A. M., Penner, R., & Kinet, J. P.
Cell 109(3), 397–407 (2002).
DOI: https://doi.org/10.1016/s0092-8674(02)00719-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12015988
Launay, P., Fleig, A., Perraud, A. L., Scharenberg, A. M., Penner, R., & Kinet, J. P.
Cell 109(3), 397–407 (2002).
DOI: https://doi.org/10.1016/s0092-8674(02)00719-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12015988
A unified nomenclature for the superfamily of TRP cation channels
Montell, C., Birnbaumer, L., Flockerzi, V., Bindels, R. J., Bruford, E. A., Caterina, M. J., Clapham, D. E., Harteneck, C., Heller, S., Julius, D., Kojima, I., Mori, Y., Penner, R., Prawitt, D., Scharenberg, A. M., Schultz, G., Shimizu, N., & Zhu, M. X.
Molecular Cell 9(2), 229–231 (2002).
DOI: https://doi.org/10.1016/S1097-2765(02)00448-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11864597
Montell, C., Birnbaumer, L., Flockerzi, V., Bindels, R. J., Bruford, E. A., Caterina, M. J., Clapham, D. E., Harteneck, C., Heller, S., Julius, D., Kojima, I., Mori, Y., Penner, R., Prawitt, D., Scharenberg, A. M., Schultz, G., Shimizu, N., & Zhu, M. X.
Molecular Cell 9(2), 229–231 (2002).
DOI: https://doi.org/10.1016/S1097-2765(02)00448-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11864597
Transient receptor potential 1 regulates capacitative Ca2+ entry and Ca2+ release from endoplasmic reticulum in B lymphocytes
Mori, Y., Wakamori, M., Miyakawa, T., Hermosura, M., Hara, Y., Nishida, M., Hirose, K., Mizushima, A., Kurosaki, M., Mori, E., Gotoh, K., Okada, T., Fleig, A., Penner, R., Iino, M., & Kurosaki, T.
The Journal of Experimental Medicine 195(6), 673–681 (2002).
DOI: https://doi.org/10.1084/jem.20011758. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193746
Mori, Y., Wakamori, M., Miyakawa, T., Hermosura, M., Hara, Y., Nishida, M., Hirose, K., Mizushima, A., Kurosaki, M., Mori, E., Gotoh, K., Okada, T., Fleig, A., Penner, R., Iino, M., & Kurosaki, T.
The Journal of Experimental Medicine 195(6), 673–681 (2002).
DOI: https://doi.org/10.1084/jem.20011758. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193746
LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability
Nadler, M. J., Hermosura, M. C., Inabe, K., Perraud, A. L., Zhu, Q., Stokes, A. J., Kurosaki, T., Kinet, J. P., Penner, R., Scharenberg, A. M., & Fleig, A.
Nature 411(6837), 590–595 (2001).
DOI: https://doi.org/10.1038/35079092. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11385574
Nadler, M. J., Hermosura, M. C., Inabe, K., Perraud, A. L., Zhu, Q., Stokes, A. J., Kurosaki, T., Kinet, J. P., Penner, R., Scharenberg, A. M., & Fleig, A.
Nature 411(6837), 590–595 (2001).
DOI: https://doi.org/10.1038/35079092. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11385574
ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology
Perraud, A. L., Fleig, A., Dunn, C. A., Bagley, L. A., Launay, P., Schmitz, C., Stokes, A. J., Zhu, Q., Bessman, M. J., Penner, R., Kinet, J. P., & Scharenberg, A. M.
Nature 411(6837), 595–599 (2001).
DOI: https://doi.org/10.1038/35079100. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11385575
Perraud, A. L., Fleig, A., Dunn, C. A., Bagley, L. A., Launay, P., Schmitz, C., Stokes, A. J., Zhu, Q., Bessman, M. J., Penner, R., Kinet, J. P., & Scharenberg, A. M.
Nature 411(6837), 595–599 (2001).
DOI: https://doi.org/10.1038/35079100. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11385575
CaT1 and the calcium release-activated calcium channel manifest distinct pore properties
Voets, T., Prenen, J., Fleig, A., Vennekens, R., Watanabe, H., Hoenderop, J. G., Bindels, R. J., Droogmans, G., Penner, R., & Nilius, B.
The Journal of Biological Chemistry 276(51), 47767–47770 (2001).
DOI: https://doi.org/10.1074/jbc.C100607200. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11687570
Voets, T., Prenen, J., Fleig, A., Vennekens, R., Watanabe, H., Hoenderop, J. G., Bindels, R. J., Droogmans, G., Penner, R., & Nilius, B.
The Journal of Biological Chemistry 276(51), 47767–47770 (2001).
DOI: https://doi.org/10.1074/jbc.C100607200. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11687570
Hearing threshold and frequency discrimination in the purely aquatic frog Xenopus laevis (Pipidae): Measurement by means of conditioning
Elepfandt, A., Eistetter, I., Fleig, A., Günther, E., Hainich, M., Hepperle, S., & Traub, B.
The Journal of Experimental Biology 203(Pt 23), 3621–3629 (2000).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/11060223
Elepfandt, A., Eistetter, I., Fleig, A., Günther, E., Hainich, M., Hepperle, S., & Traub, B.
The Journal of Experimental Biology 203(Pt 23), 3621–3629 (2000).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/11060223
InsP4 facilitates store-operated calcium influx by inhibition of InsP3 5-phosphatase
Hermosura, M. C., Takeuchi, H., Fleig, A., Riley, A. M., Potter, B. V., Hirata, M., & Penner, R.
Nature 408(6813), 735–740 (2000).
DOI: https://doi.org/10.1038/35047115. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11130077
Hermosura, M. C., Takeuchi, H., Fleig, A., Riley, A. M., Potter, B. V., Hirata, M., & Penner, R.
Nature 408(6813), 735–740 (2000).
DOI: https://doi.org/10.1038/35047115. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11130077
Previous Publications
Differential modulation of voltage-dependent Ca2+ currents by EGTA and BAPTA in bovine adrenal chromaffin cells
Bödding, M., & Penner, R.
Pflugers Archiv: European Journal of Physiology 439(1–2), 27–38 (1999).
DOI: https://doi.org/10.1007/s004249900158. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10650997
Bödding, M., & Penner, R.
Pflugers Archiv: European Journal of Physiology 439(1–2), 27–38 (1999).
DOI: https://doi.org/10.1007/s004249900158. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10650997
Calcium release-activated calcium current (ICRAC) is a direct target for sphingosine
Mathes, C., Fleig, A., & Penner, R.
The Journal of Biological Chemistry 273(39), 25020–25030 (1998).
DOI: https://doi.org/10.1074/jbc.273.39.25020. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9737958
Mathes, C., Fleig, A., & Penner, R.
The Journal of Biological Chemistry 273(39), 25020–25030 (1998).
DOI: https://doi.org/10.1074/jbc.273.39.25020. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9737958
Near-visible ultraviolet light induces a novel ubiquitous calcium-permeable cation current in mammalian cell lines
Mendez, F., & Penner, R.
The Journal of Physiology 507 ( Pt 2), 365–377 (1998).
DOI: https://doi.org/10.1111/j.1469-7793.1998.365bt.x. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2230791
Mendez, F., & Penner, R.
The Journal of Physiology 507 ( Pt 2), 365–377 (1998).
DOI: https://doi.org/10.1111/j.1469-7793.1998.365bt.x. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2230791
The store-operated calcium current ICRAC: Nonlinear activation by InsP3 and dissociation from calcium release
Parekh, A. B., Fleig, A., & Penner, R.
Cell 89(6), 973–980 (1997).
DOI: https://doi.org/10.1016/s0092-8674(00)80282-2. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9200615
Parekh, A. B., Fleig, A., & Penner, R.
Cell 89(6), 973–980 (1997).
DOI: https://doi.org/10.1016/s0092-8674(00)80282-2. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9200615
Effects of clamp rise-time on rat brain IIA sodium channels in Xenopus oocytes
Ruben, P. C., Fleig, A., Featherstone, D., Starkus, J. G., & Rayner, M. D.
Journal of Neuroscience Methods 73(2), 113–122 (1997).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/9196281
Ruben, P. C., Fleig, A., Featherstone, D., Starkus, J. G., & Rayner, M. D.
Journal of Neuroscience Methods 73(2), 113–122 (1997).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/9196281
Store depletion and calcium influx
Parekh, A. B., & Penner, R.
Physiological Reviews 77(4), 901–930 (1997).
DOI: https://doi.org/10.1152/physrev.1997.77.4.901. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9354808
Parekh, A. B., & Penner, R.
Physiological Reviews 77(4), 901–930 (1997).
DOI: https://doi.org/10.1152/physrev.1997.77.4.901. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9354808
Ca2+-induced Ca2+ release in Chinese hamster ovary (CHO) cells co-expressing dihydropyridine and ryanodine receptors
Suda, N., Franzius, D., Fleig, A., Nishimura, S., Bödding, M., Hoth, M., Takeshima, H., & Penner, R.
The Journal of General Physiology 109(5), 619–631 (1997).
DOI: https://doi.org/10.1085/jgp.109.5.619. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217062
Suda, N., Franzius, D., Fleig, A., Nishimura, S., Bödding, M., Hoth, M., Takeshima, H., & Penner, R.
The Journal of General Physiology 109(5), 619–631 (1997).
DOI: https://doi.org/10.1085/jgp.109.5.619. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217062
Acceleration of membrane recycling by axotomy of cultured Aplysia neurons
Ashery, U., Penner, R., & Spira, M. E.
Neuron 16(3), 641–651 (1996).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/8785061
Ashery, U., Penner, R., & Spira, M. E.
Neuron 16(3), 641–651 (1996).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/8785061
Silent calcium channels generate excessive tail currents and facilitation of calcium currents in rat skeletal myoballs
Fleig, A., & Penner, R.
The Journal of Physiology 494 ( Pt 1), 141–153 (1996).
DOI: https://doi.org/10.1113/jphysiol.1996.sp021481. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160620
Fleig, A., & Penner, R.
The Journal of Physiology 494 ( Pt 1), 141–153 (1996).
DOI: https://doi.org/10.1113/jphysiol.1996.sp021481. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160620
Absence of Ca2+ current facilitation in skeletal muscle of transgenic mice lacking the type 1 ryanodine receptor
Fleig, A., Takeshima, H., & Penner, R.
The Journal of Physiology 496 ( Pt 2), 339–345 (1996).
DOI: https://doi.org/10.1113/jphysiol.1996.sp021689. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160881
Fleig, A., Takeshima, H., & Penner, R.
The Journal of Physiology 496 ( Pt 2), 339–345 (1996).
DOI: https://doi.org/10.1113/jphysiol.1996.sp021689. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160881
Regulation of store-operated calcium currents in mast cells
Parekh, A. B., & Penner, R.
Society of General Physiologists Series 51, 231–239 (1996).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/8809947
Parekh, A. B., & Penner, R.
Society of General Physiologists Series 51, 231–239 (1996).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/8809947
Characterization of the Ca2+ current in isolated terminals of crustacean peptidergic neurons
Richmond, J. E., Penner, R., Keller, R., & Cooke, I. M.
The Journal of Experimental Biology 199(Pt 9), 2053–2059 (1996).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/8831146
Richmond, J. E., Penner, R., Keller, R., & Cooke, I. M.
The Journal of Experimental Biology 199(Pt 9), 2053–2059 (1996).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/8831146
Excessive repolarization-dependent calcium currents induced by strong depolarizations in rat skeletal myoballs
Fleig, A., & Penner, R.
The Journal of Physiology 489 ( Pt 1), 41–53 (1995).
DOI: https://doi.org/10.1113/jphysiol.1995.sp021028. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156790
Fleig, A., & Penner, R.
The Journal of Physiology 489 ( Pt 1), 41–53 (1995).
DOI: https://doi.org/10.1113/jphysiol.1995.sp021028. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156790
Activation of store-operated calcium influx at resting InsP3 levels by sensitization of the InsP3 receptor in rat basophilic leukaemia cells
Parekh, A. B., & Penner, R.
The Journal of Physiology 489 ( Pt 2), 377–382 (1995).
DOI: https://doi.org/10.1113/jphysiol.1995.sp021058. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156765
Parekh, A. B., & Penner, R.
The Journal of Physiology 489 ( Pt 2), 377–382 (1995).
DOI: https://doi.org/10.1113/jphysiol.1995.sp021058. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156765
Depletion-activated calcium current is inhibited by protein kinase in RBL-2H3 cells
Parekh, A. B., & Penner, R.
Proceedings of the National Academy of Sciences of the United States of America 92(17), 7907–7911 (1995).
DOI: https://doi.org/10.1073/pnas.92.17.7907. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC41255
Parekh, A. B., & Penner, R.
Proceedings of the National Academy of Sciences of the United States of America 92(17), 7907–7911 (1995).
DOI: https://doi.org/10.1073/pnas.92.17.7907. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC41255
Non-specific effects of calcium entry antagonists in mast cells
Franzius, D., Hoth, M., & Penner, R.
Pflugers Archiv: European Journal of Physiology 428(5–6), 433–438 (1994).
DOI: https://doi.org/10.1007/bf00374562. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7838664
Franzius, D., Hoth, M., & Penner, R.
Pflugers Archiv: European Journal of Physiology 428(5–6), 433–438 (1994).
DOI: https://doi.org/10.1007/bf00374562. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7838664
Mice sans synaptotagmin
Neher, E., & Penner, R.
Nature 372(6504), 316–317 (1994).
DOI: https://doi.org/10.1038/372316a0. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7969483
Neher, E., & Penner, R.
Nature 372(6504), 316–317 (1994).
DOI: https://doi.org/10.1038/372316a0. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7969483
Membrane repolarization stops caffeine-induced Ca2+ release in skeletal muscle cells
Suda, N., & Penner, R.
Proceedings of the National Academy of Sciences of the United States of America 91(12), 5725–5729 (1994).
DOI: https://doi.org/10.1073/pnas.91.12.5725. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC44069
Suda, N., & Penner, R.
Proceedings of the National Academy of Sciences of the United States of America 91(12), 5725–5729 (1994).
DOI: https://doi.org/10.1073/pnas.91.12.5725. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC44069
Point mutations in IIS4 alter activation and inactivation of rat brain IIA Na channels in Xenopus oocyte macropatches
Fleig, A., Fitch, J. M., Goldin, A. L., Rayner, M. D., Starkus, J. G., & Ruben, P. C.
Pflügers Archiv: European Journal of Physiology 427(5–6), 406–413 (1994).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/7971139
Fleig, A., Fitch, J. M., Goldin, A. L., Rayner, M. D., Starkus, J. G., & Ruben, P. C.
Pflügers Archiv: European Journal of Physiology 427(5–6), 406–413 (1994).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/7971139
Kinetic mode switch of rat brain IIA Na channels in Xenopus oocytes excised macropatches
Fleig, A., Ruben, P. C., & Rayner, M. D.
Pflügers Archiv: European Journal of Physiology 427(5–6), 399–405 (1994).
DOI: https//doi.org/10.1007/bf00374253. PMID: https://www.ncbi.nlm.nih.gov/pubmed/797113
Fleig, A., Ruben, P. C., & Rayner, M. D.
Pflügers Archiv: European Journal of Physiology 427(5–6), 399–405 (1994).
DOI: https//doi.org/10.1007/bf00374253. PMID: https://www.ncbi.nlm.nih.gov/pubmed/797113
Fast and slow inactivation of sodium channels: Effects of photodynamic modification by methylene blue
Starkus, J. G., Rayner, M. D., Fleig, A., & Ruben, P. C.
Biophysical Journal 65(2), 715–726 (1993).
DOI: https://doi.org/10.1016/S0006-3495(93)81098-1. PMID: https://www.ncbi.nlm.nih.gov/pubmed/821889
Starkus, J. G., Rayner, M. D., Fleig, A., & Ruben, P. C.
Biophysical Journal 65(2), 715–726 (1993).
DOI: https://doi.org/10.1016/S0006-3495(93)81098-1. PMID: https://www.ncbi.nlm.nih.gov/pubmed/821889
Ca2+ and Mn2+ influx through receptor-mediated activation of nonspecific cation channels in mast cells
Fasolato, C., Hoth, M., Matthews, G., & Penner, R.
Proceedings of the National Academy of Sciences of the United States of America 90(7), 3068–3072 (1993).
DOI: https://doi.org/10.1073/pnas.90.7.3068. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC46238
Fasolato, C., Hoth, M., Matthews, G., & Penner, R.
Proceedings of the National Academy of Sciences of the United States of America 90(7), 3068–3072 (1993).
DOI: https://doi.org/10.1073/pnas.90.7.3068. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC46238
A GTP-dependent step in the activation mechanism of capacitative calcium influx
Fasolato, C., Hoth, M., & Penner, R.
The Journal of Biological Chemistry 268(28), 20737–20740 (1993).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/8407897
Fasolato, C., Hoth, M., & Penner, R.
The Journal of Biological Chemistry 268(28), 20737–20740 (1993).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/8407897
Multiple mechanisms of manganese-induced quenching of fura-2 fluorescence in rat mast cells
Fasolato, C., Hoth, M., & Penner, R.
Pflugers Archiv: European Journal of Physiology 423(3–4), 225–231 (1993).
DOI: https://doi.org/10.1007/bf00374399. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8321625
Fasolato, C., Hoth, M., & Penner, R.
Pflugers Archiv: European Journal of Physiology 423(3–4), 225–231 (1993).
DOI: https://doi.org/10.1007/bf00374399. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8321625
Ion channels and calcium signaling in mast cells
Hoth, M., Fasolato, C., & Penner, R.
Annals of the New York Academy of Sciences 707, 198–209 (1993).
DOI: https://doi.org/10.1111/j.1749-6632.1993.tb38053.x. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9137553
Hoth, M., Fasolato, C., & Penner, R.
Annals of the New York Academy of Sciences 707, 198–209 (1993).
DOI: https://doi.org/10.1111/j.1749-6632.1993.tb38053.x. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9137553
Calcium release-activated calcium current in rat mast cells
Hoth, M., & Penner, R.
The Journal of Physiology 465, 359–386 (1993).
DOI: https://doi.org/10.1113/jphysiol.1993.sp019681. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175434
Hoth, M., & Penner, R.
The Journal of Physiology 465, 359–386 (1993).
DOI: https://doi.org/10.1113/jphysiol.1993.sp019681. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175434
Calcium influx and its control by calcium release
Penner, R., Fasolato, C., & Hoth, M.
Current Opinion in Neurobiology 3(3), 368–374 (1993).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/8396477
Penner, R., Fasolato, C., & Hoth, M.
Current Opinion in Neurobiology 3(3), 368–374 (1993).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/8396477
Transfected cGMP-dependent protein kinase suppresses calcium transients by inhibition of inositol 1,4,5-trisphosphate production
Ruth, P., Wang, G. X., Boekhoff, I., May, B., Pfeifer, A., Penner, R., Korth, M., Breer, H., & Hofmann, F.
Proceedings of the National Academy of Sciences of the United States of America 90(7), 2623–2627 (1993).
DOI: https://doi.org/10.1073/pnas.90.7.2623. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC46147
Ruth, P., Wang, G. X., Boekhoff, I., May, B., Pfeifer, A., Penner, R., Korth, M., Breer, H., & Hofmann, F.
Proceedings of the National Academy of Sciences of the United States of America 90(7), 2623–2627 (1993).
DOI: https://doi.org/10.1073/pnas.90.7.2623. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC46147
Depletion of intracellular calcium stores activates a calcium current in mast cells
Hoth, M., & Penner, R.
Nature 355(6358), 353–356 (1992).
DOI: https://doi.org/10.1038/355353a0. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1309940
Hoth, M., & Penner, R.
Nature 355(6358), 353–356 (1992).
DOI: https://doi.org/10.1038/355353a0. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1309940
Novel chloride conductance in the membrane of bovine chromaffin cells activated by intracellular GTP gamma S
Doroshenko, P., Penner, R., & Neher, E.
The Journal of Physiology 436, 711–724 (1991).
DOI: https://doi.org/10.1113/jphysiol.1991.sp018575. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1181530
Doroshenko, P., Penner, R., & Neher, E.
The Journal of Physiology 436, 711–724 (1991).
DOI: https://doi.org/10.1113/jphysiol.1991.sp018575. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1181530
Guanosine 5’-[beta-thio]triphosphate selectively activates calcium signaling in mast cells
von zur Mühlen, F., Eckstein, F., & Penner, R.
Proceedings of the National Academy of Sciences of the United States of America 88(3), 926–930 (1991).
DOI: https://doi.org/10.1073/pnas.88.3.926. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC50927
von zur Mühlen, F., Eckstein, F., & Penner, R.
Proceedings of the National Academy of Sciences of the United States of America 88(3), 926–930 (1991).
DOI: https://doi.org/10.1073/pnas.88.3.926. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC50927
A GTP analogue induces calcium release but not secretion in rat mast cells
von zur Mühlen, F., & Penner, R.
International Archives of Allergy and Applied Immunology 94(1–4), 74–75 (1991).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/1657794
von zur Mühlen, F., & Penner, R.
International Archives of Allergy and Applied Immunology 94(1–4), 74–75 (1991).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/1657794
Effects of angiotensin II on intracellular calcium and electrical function of mouse renal juxtaglomerular cells
Kurtz, A., & Penner, R.
Kidney International. Supplement 30, S51-54 (1990).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/2175372
Kurtz, A., & Penner, R.
Kidney International. Supplement 30, S51-54 (1990).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/2175372
Lack of direct evidence for a functional role of voltage-operated calcium channels in juxtaglomerular cells
Kurtz, A., Skott, O., Chegini, S., & Penner, R.
Pflugers Archiv: European Journal of Physiology 416(3), 281–287 (1990).
DOI: https://doi.org/10.1007/bf00392064. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2166274
Kurtz, A., Skott, O., Chegini, S., & Penner, R.
Pflugers Archiv: European Journal of Physiology 416(3), 281–287 (1990).
DOI: https://doi.org/10.1007/bf00392064. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2166274
Angiotensin II induces oscillations of intracellular calcium and blocks anomalous inward rectifying potassium current in mouse renal juxtaglomerular cells
Kurtz, A., & Penner, R.
Proceedings of the National Academy of Sciences of the United States of America 86(9), 3423–3427 (1989).
DOI: https://doi.org/10.1073/pnas.86.9.3423. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC287145
Kurtz, A., & Penner, R.
Proceedings of the National Academy of Sciences of the United States of America 86(9), 3423–3427 (1989).
DOI: https://doi.org/10.1073/pnas.86.9.3423. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC287145
Chloride conductance activated by external agonists and internal messengers in rat peritoneal mast cells
Matthews, G., Neher, E., & Penner, R.
The Journal of Physiology 418, 131–144 (1989).
DOI: https://doi.org/10.1113/jphysiol.1989.sp017831. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1189962
Matthews, G., Neher, E., & Penner, R.
The Journal of Physiology 418, 131–144 (1989).
DOI: https://doi.org/10.1113/jphysiol.1989.sp017831. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1189962
Second messenger-activated calcium influx in rat peritoneal mast cells
Matthews, G., Neher, E., & Penner, R.
The Journal of Physiology 418, 105–130 (1989).
DOI: https://doi.org/10.1113/jphysiol.1989.sp017830. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1189961
Matthews, G., Neher, E., & Penner, R.
The Journal of Physiology 418, 105–130 (1989).
DOI: https://doi.org/10.1113/jphysiol.1989.sp017830. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1189961
Stimulus-secretion coupling in mast cells
Penner, R., & Neher, E.
Society of General Physiologists Series 44, 295–310 (1989).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/2781355
Penner, R., & Neher, E.
Society of General Physiologists Series 44, 295–310 (1989).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/2781355
[The importance of calcium for secretion in excitable and non-excitable cells]
Penner, R., & Neher, E.
Arzneimittel-Forschung 39(1A), 174–177 (1989).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/2655617
Penner, R., & Neher, E.
Arzneimittel-Forschung 39(1A), 174–177 (1989).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/2655617
The patch-clamp technique in the study of secretion
Penner, R., & Neher, E.
Trends in Neurosciences 12(4), 159–163 (1989).
DOI: https://doi.org/10.1016/0166-2236(89)90059-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2470174
Penner, R., & Neher, E.
Trends in Neurosciences 12(4), 159–163 (1989).
DOI: https://doi.org/10.1016/0166-2236(89)90059-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2470174
Functional expression of the calcium release channel from skeletal muscle ryanodine receptor cDNA
Penner, R., Neher, E., Takeshima, H., Nishimura, S., & Numa, S.
FEBS Letters 259(1), 217–221 (1989).
DOI: https://doi.org/10.1016/0014-5793(89)81532-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2557244
Penner, R., Neher, E., Takeshima, H., Nishimura, S., & Numa, S.
FEBS Letters 259(1), 217–221 (1989).
DOI: https://doi.org/10.1016/0014-5793(89)81532-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2557244
Multiple signaling pathways control stimulus-secretion coupling in rat peritoneal mast cells
Penner, R.
Proceedings of the National Academy of Sciences of the United States of America 85(24), 9856–9860 (1988).
DOI: https://doi.org/10.1073/pnas.85.24.9856. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC282880
Penner, R.
Proceedings of the National Academy of Sciences of the United States of America 85(24), 9856–9860 (1988).
DOI: https://doi.org/10.1073/pnas.85.24.9856. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC282880
Regulation of calcium influx by second messengers in rat mast cells
Penner, R., Matthews, G., & Neher, E.
Nature 334(6182), 499–504 (1988).
DOI: https://doi.org/10.1038/334499a0. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2457169
Penner, R., Matthews, G., & Neher, E.
Nature 334(6182), 499–504 (1988).
DOI: https://doi.org/10.1038/334499a0. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2457169
Secretory responses of rat peritoneal mast cells to high intracellular calcium
Penner, R., & Neher, E.
FEBS Letters 226(2), 307–313 (1988).
DOI: https://doi.org/10.1016/0014-5793(88)81445-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/3123272
Penner, R., & Neher, E.
FEBS Letters 226(2), 307–313 (1988).
DOI: https://doi.org/10.1016/0014-5793(88)81445-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/3123272
The role of calcium in stimulus-secretion coupling in excitable and non-excitable cells
Penner, R., & Neher, E.
The Journal of Experimental Biology 139, 329–345 (1988).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/2850338
Penner, R., & Neher, E.
The Journal of Experimental Biology 139, 329–345 (1988).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/2850338
The actions of presynaptic snake toxins on membrane currents of mouse motor nerve terminals
Dreyer, F., & Penner, R.
The Journal of Physiology 386, 455–463 (1987).
DOI: https://doi.org/10.1113/jphysiol.1987.sp016544. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1192472
Dreyer, F., & Penner, R.
The Journal of Physiology 386, 455–463 (1987).
DOI: https://doi.org/10.1113/jphysiol.1987.sp016544. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1192472
Differential effects of various secretagogues on quantal transmitter release from mouse motor nerve terminals treated with botulinum A and tetanus toxin
Dreyer, F., Rosenberg, F., Becker, C., Bigalke, H., & Penner, R.
Naunyn-Schmiedeberg’s Archives of Pharmacology 335(1), 1–7 (1987).
DOI: https://doi.org/10.1007/bf00165027. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2883583
Dreyer, F., Rosenberg, F., Becker, C., Bigalke, H., & Penner, R.
Naunyn-Schmiedeberg’s Archives of Pharmacology 335(1), 1–7 (1987).
DOI: https://doi.org/10.1007/bf00165027. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2883583
Distinct sites of action of clostridial neurotoxins revealed by double-poisoning of mouse motor nerve terminals
Gansel, M., Penner, R., & Dreyer, F.
Pflugers Archiv: European Journal of Physiology 409(4–5), 533–539 (1987).
DOI: https://doi.org/10.1007/bf00583812. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2888074
Gansel, M., Penner, R., & Dreyer, F.
Pflugers Archiv: European Journal of Physiology 409(4–5), 533–539 (1987).
DOI: https://doi.org/10.1007/bf00583812. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2888074
Washout phenomena in dialyzed mast cells allow discrimination of different steps in stimulus-secretion coupling
Penner, R., Pusch, M., & Neher, E.
Bioscience Reports 7(4), 313–321 (1987).
DOI: https://doi.org/10.1007/bf01121453. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2445392
Penner, R., Pusch, M., & Neher, E.
Bioscience Reports 7(4), 313–321 (1987).
DOI: https://doi.org/10.1007/bf01121453. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2445392
Two different presynaptic calcium currents in mouse motor nerve terminals
Penner, R., & Dreyer, F.
Pflugers Archiv: European Journal of Physiology 406(2), 190–197 (1986).
DOI: https://doi.org/10.1007/bf00586682. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2421238
Penner, R., & Dreyer, F.
Pflugers Archiv: European Journal of Physiology 406(2), 190–197 (1986).
DOI: https://doi.org/10.1007/bf00586682. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2421238
Intracellularly injected tetanus toxin inhibits exocytosis in bovine adrenal chromaffin cells
Penner, R., Neher, E., & Dreyer, F.
Nature 324(6092), 76–78 (1986).
DOI: https://doi.org/10.1038/324076a0. PMID: https://www.ncbi.nlm.nih.gov/pubmed/3785374
Penner, R., Neher, E., & Dreyer, F.
Nature 324(6092), 76–78 (1986).
DOI: https://doi.org/10.1038/324076a0. PMID: https://www.ncbi.nlm.nih.gov/pubmed/3785374
Dendrotoxin: A selective blocker of a non-inactivating potassium current in guinea-pig dorsal root ganglion neurones
Penner, R., Petersen, M., Pierau, F. K., & Dreyer, F.
Pflugers Archiv: European Journal of Physiology 407(4), 365–369 (1986).
DOI: https://doi.org/10.1007/bf00652619. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2430257
Penner, R., Petersen, M., Pierau, F. K., & Dreyer, F.
Pflugers Archiv: European Journal of Physiology 407(4), 365–369 (1986).
DOI: https://doi.org/10.1007/bf00652619. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2430257
Beta-bungarotoxin inhibits a non-inactivating potassium current in guinea pig dorsal root ganglion neurones
Petersen, M., Penner, R., Pierau, F. K., & Dreyer, F.
Neuroscience Letters 68(1), 141–145 (1986).
DOI: https://doi.org/10.1016/0304-3940(86)90244-2. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2425306
Petersen, M., Penner, R., Pierau, F. K., & Dreyer, F.
Neuroscience Letters 68(1), 141–145 (1986).
DOI: https://doi.org/10.1016/0304-3940(86)90244-2. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2425306
Action of botulinum A toxin and tetanus toxin on synaptic transmission
Dreyer, F., Becker, C., Bigalke, H., Funk, J., Penner, R., Rosenberg, F., & Ziegler, M.
Journal De Physiologie 79(4), 252–258 (1984).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/6152293
Dreyer, F., Becker, C., Bigalke, H., Funk, J., Penner, R., Rosenberg, F., & Ziegler, M.
Journal De Physiologie 79(4), 252–258 (1984).
PMID: https://www.ncbi.nlm.nih.gov/pubmed/6152293