A manuscript by Drs. Sumoza-Toledo and Penner has been honored by The Journal of Physiology, England for being cited 100 times within 10 years. Authors having achieved that receive the distinction of “Century Citation Club”, also accessible on the journal’s webpage. 

The paper receiving the honor: 
 TRPM2: a multifunctional ion channel for calcium signalling , 2011

Here is the editorial explaining the Century Citation Club:
https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/jphysiol.2011.209122

A brief sample excerpt:…[The Century Citation Club comprises research papers which attract over 100 citations within ten years of publication. This is an achievement that we certainly think is worth recognition and celebration: everyone knows that papers are more often cited for being right than for being wrong or boring (or both). One hundred citations represents a citation rate roughly twice the average for the Journal of Physiology and then maintained for a decade; these papers are exceptional, they have made their mark and changed their fields.]...

Dr. Suzuki’s most recent publication in Cell Molecular Life Sciences further highlights the emerging picture of TRPM7’s regulatory participation in cellular calcium signaling. The study finds that TRPM7 kinase phosphorylation activity is required for orderly signaling downstream of Gq. This mechanism may support limiting GPCR-mediated calcium signaling in times of insufficient cellular ATP supply.

Tune in to learn about more about autoimmune disease, what to look out for, treatments, and what the future of medicine might bring in helping people with the disease. Dr. Fleig is Associate Director of Biomedical Research at The Queen’s Medical Center and co-founder of a biomedical start-up to translate research done at QCBR into patient care. ThinkTech's vision is to be a leader in shaping a more vital and thriving Hawaii as the foundation for future generations.
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Earlier this year, the team at QCBR was recognized for its vision and research by receiving the "Eli Lilly Outstanding Contribution to Drug Discovery: Enabling Biology 2016 Award".

Congratulations Aaron, Alex, Andrea, Clay, Mahea, Malika, Reinhold and Sayuri. 

The current issue of The Journal of Physiology, London (Vol. 595, 2017) contains reviews and original papers contributed by speakers presenting at a meeting held in Honolulu, April 2016: Breakthroughs and Advances in Calcium Signaling. The meeting was generously sponsored by The Journal of Physiology, The Queen’s Health Systems, University of Hawaii Systems, Hamamatsu Photonics, Janssen, Novartis, INBRE III, nanion, Sophion, and Charles River. Lead organizer was Dr. Penner, supported by Dr. Fleig and Dr. Anant Parekh (Oxford). For more information about the conference, please visit http://calcium-signaling.weebly.com

Fleig A, Parekh AB. New insights into Ca2+ channel function in health and disease. J Physiol. 2017 May 15;595(10):2997-2998. doi: 10.1113/JP274289. PMED ID: 28503825.

The most lethal form of malaria in humans is caused by Plasmodium falciparum. In collaboration with Dr. Alan Cowman’s (Melbourne) and Dr. David Horgen’s (Honolulu) group, a manuscript has just been accepted by eLIFE implicating TRPM7 as a target in malaria prevention. The work shows that TRPM7, the magnesium ion channel discovered by Dr. Fleig in 2001, enables parasite invasion in human erythrocytes. QCBR and collaborators have discovered waxenicin A as a specific blocker of TRPM7. By using that compound, parasite invasion is prevented in vitro.